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In Defense Of The Amyloid Hypothesis

A guest post defending the amyloid hypothesis of Alzheimer's disease, explaining why amyloid is likely the root cause despite recent criticism and discussing why early treatments have only been partially effective.

acx
Aug 14, 2025 10,813 words 279 likes 188 comments Listen · 35 min Read Read

Your Review: Of Mice, Mechanisms, and Dementia

A detailed review of a 1995 paper introducing the PDAPP mouse model for Alzheimer's disease, examining how its limitations were overlooked and shaped decades of potentially misguided Alzheimer's research.

acx
Jul 11, 2025 7,754 words 184 likes 170 comments Listen · 48 min Read Read
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