Scott examines new research on ketamine's antidepressant effects and its implications for understanding depression and evaluating psychiatric literature. Longer summary

This post discusses new research on ketamine's antidepressant effects, which suggests they are caused by a metabolite rather than ketamine itself. The author examines how this finding impacts previous research and understanding of ketamine's mechanism of action. He reviews studies on NMDA antagonists and finds mixed results, with some potential bias when conflicts of interest are present. The post concludes by reflecting on the implications for trusting psychiatric literature, especially in cases with conflicts of interest. Shorter summary