Want to dive into Scott Alexander's work and his thousands of blog posts? This fan website lets you sort and do semantic search through the whole codex. Enjoy!
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A guest post defending the amyloid hypothesis of Alzheimer's disease, explaining why amyloid is likely the root cause despite recent criticism and discussing why early treatments have only been partially effective.
A detailed review of a 1995 paper introducing the PDAPP mouse model for Alzheimer's disease, examining how its limitations were overlooked and shaped decades of potentially misguided Alzheimer's research.
Scott Alexander critiques a study suggesting knowledge of ApoE4 gene status affects memory performance, arguing the results may be due to priming or stereotype threat rather than actual memory decline.
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