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opioid receptors (2)
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study critique (270)
book review (221)
AI (112)
economics (105)
effective altruism (105)
education (93)
creative writing (89)
forecasting (89)
politics (89)
prediction markets (88)
debate (87)
science (85)
AI safety (78)
media criticism (76)
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psychiatry (73)
psychology (72)
rationality (71)
mental health (69)
highlights from the comments (68)
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2 posts
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reinforcement learning (13) dopamine (7) alcoholism (5) reward system (3) addiction treatment (3) opioid receptors (2)

Antagonizing Opioid Receptors for (Prevention of) Fun and Profit

Scott explains how the Sinclair Method treats alcoholism by using naltrexone to block the brain's reward response to alcohol, breaking the learned association between drinking and pleasure through temporal difference learning.

lw
May 5, 2010 1,281 words 57 likes 35 comments Read Read
neuroscience (75) wireheading (10) dopamine (7) AI goals (4) utility (3) revealed preferences (3) procrastination (3) opioid receptors (2) utilitarian (2) wanting vs liking (2)

Are wireheads happy?

Scott discusses the neuroscientific split between 'wanting' and 'liking', showing how wireheads might not actually be happy, and explores the troubling implications this has for economics, philosophy, and AI alignment.

lw
Jan 1, 2010 1,606 words 189 likes 109 comments Read Read
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