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Mar 16, 2022
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Highlights From The Comments On Zulresso

13 min • 1,804 words • 17 comments • 37 likes • podcast (14 min)
Scott Alexander highlights and responds to expert comments on his previous posts about Zulresso and Zuranolone, covering various aspects of these drugs and related topics. Longer summary
Scott Alexander summarizes and responds to comments on his previous posts about Zulresso and Zuranolone. The post covers various topics including drug pricing, mechanism details of GABA receptors, etymology of drug names, tolerance development, progesterone's effects, and personal experiences with progesterone. Scott expresses appreciation for the expertise of his commenters, particularly in biomedical topics, and acknowledges learning new information from them. Shorter summary
Mar 10, 2022
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Progesterone Megadoses Might Be A Cheap Zulresso Substitute

5 min • 693 words • 88 comments • 52 likes • podcast (8 min)
Scott Alexander proposes using high-dose oral progesterone as a potential low-cost alternative to Zulresso for treating postpartum depression, based on pharmacological research. Longer summary
Scott Alexander explores the possibility of using high-dose progesterone as a cheaper alternative to Zulresso for treating postpartum depression. He explains that Zulresso is a metabolite of progesterone and presents research suggesting that a specific regimen of oral progesterone could potentially mimic the effects of Zulresso. The post discusses the pharmacokinetics, dosing schedule, and potential cost savings, with progesterone treatment costing only about $11 compared to Zulresso's $35,000. Scott acknowledges potential obstacles in implementation but hopes researchers will investigate this approach further. Shorter summary
Mar 08, 2022
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Zounds! It's Zulresso and Zuranolone!

26 min • 3,635 words • 117 comments • 70 likes • podcast (30 min)
Scott Alexander examines Zulresso and Zuranolone, two neurosteroid drugs for postpartum depression, discussing their efficacy, challenges, and potential future applications. Longer summary
Scott Alexander discusses Zulresso (allopregnanolone) and Zuranolone, two related drugs for treating postpartum depression. He explains their mechanisms, efficacy, and the challenges in their development and usage. The post covers the history of allopregnanolone research, its connection to GABA and hormones, clinical trials, and potential future applications. Scott also discusses the high cost of Zulresso, its limited availability, and the mixed results of Zuranolone in treating regular depression and anxiety. The post ends with predictions about the future of these drugs and related research. Shorter summary