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Tag: mTOR

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Dec 02, 2021
acx
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29 min 4,423 words 548 comments 159 likes podcast (33 min)
Scott Alexander reviews David Sinclair's optimistic book on anti-aging research, discussing its main claims and potential criticisms. Longer summary
Scott Alexander reviews David Sinclair's book 'Lifespan', which argues that aging is primarily caused by epigenetic damage and can be easily solved. Sinclair proposes activating sirtuin proteins through various means like calorie restriction, exercise, or supplements to repair this damage. The review covers Sinclair's main arguments, potential criticisms, and broader philosophical questions about extending human lifespan. Scott expresses some skepticism about Sinclair's optimism but acknowledges the potential benefits of anti-aging research. Shorter summary