Scott analyzes various criticisms of antidepressants, concluding they have modest but real benefits over placebo, with important considerations about side effects and efficacy. Longer summary

This post examines various criticisms of SSRIs and antidepressants, addressing claims about their efficacy, side effects, and comparisons to placebo and psychotherapy. Scott analyzes studies on antidepressant effectiveness, discussing issues like publication bias, effect sizes, and the meaning of 'clinical significance'. He explores side effects, particularly sexual dysfunction, weight gain, and emotional blunting. The post concludes that while antidepressants are not miracle drugs, they do have a modest but statistically significant benefit over placebo and can be a reasonable option for many people with depression, especially if they understand and prepare for potential side effects. Shorter summary

Scott explores the fascinating etymology of 'placebo' from medieval funerals to medicine, then discusses the controversial placebo effect in depression treatment. Longer summary

This post explores the etymology of the word 'placebo' and its journey from funeral rites to medical terminology. Scott starts by debunking the common medical school explanation and delves into its medieval origins as part of funeral rites. He then discusses various theories on how it became an insult and eventually a medical term. The post then shifts to discussing the placebo effect in depression treatment, highlighting the controversy surrounding its effectiveness and the importance of understanding its true nature for patient care. Shorter summary