Scott examines studies linking sleeping pills to increased mortality, highlighting a new study that found no link after adjusting for 300 confounders, potentially challenging the validity of less thorough studies. Longer summary

Scott Alexander discusses a controversial topic in medical research: the link between sleeping pills and increased mortality. He reviews several studies that found a strong association between sleeping pill use and higher death rates from various causes, even after controlling for confounders. However, he then introduces a new study by Patorno et al. that found no such link for benzodiazepines. The key difference is that this study adjusted for an unprecedented 300 confounders using a new statistical algorithm. Scott suggests that if this study is correct, it could mean that many other medical studies that only control for a handful of confounders might be inadequate. He draws parallels to other fields where dramatically increasing scale or intensity has led to new insights. Shorter summary