Scott examines studies linking sleeping pills to increased mortality, highlighting a new study that found no link after adjusting for 300 confounders, potentially challenging the validity of less thorough studies. Longer summary

Scott Alexander discusses a controversial topic in medical research: the link between sleeping pills and increased mortality. He reviews several studies that found a strong association between sleeping pill use and higher death rates from various causes, even after controlling for confounders. However, he then introduces a new study by Patorno et al. that found no such link for benzodiazepines. The key difference is that this study adjusted for an unprecedented 300 confounders using a new statistical algorithm. Scott suggests that if this study is correct, it could mean that many other medical studies that only control for a handful of confounders might be inadequate. He draws parallels to other fields where dramatically increasing scale or intensity has led to new insights. Shorter summary

Scott Alexander explores the complexities and inconsistencies of drug tolerance in psychiatry, highlighting how different drugs can produce varying tolerance effects across individuals. Longer summary

Scott Alexander discusses the complex and often unpredictable nature of drug tolerance in psychiatry. He explores various examples of how different drugs can lead to tolerance, no tolerance, or even reverse tolerance (increased sensitivity) in different individuals. The post highlights the inconsistencies in how tolerance develops across various drugs and patients, and how this impacts psychiatric treatment. Scott expresses frustration with the lack of attention given to tolerance in psychiatric literature and the difficulty in predicting or explaining tolerance patterns. He also touches on how this unpredictability relates to addiction, the potential for missed opportunities in drug development, and the need for better understanding of tolerance mechanisms. Shorter summary