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Tag: multifactorial problems

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Mar 26, 2026
acx
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6 min 820 words 196 comments 230 likes podcast (6 min)
Scott discusses how new schizophrenia genetics research confirms that psychiatric conditions combine both 'tradeoff' components (with compensating advantages) and 'failure' components (purely negative), then argues this pattern is common sense for any multifactorial problem. Longer summary
Scott discusses new research on schizophrenia genetics which found two distinct components: one shared with bipolar that increases educational attainment (a tradeoff), and one that decreases IQ (a pure failure). He connects this to his 2021 post on tradeoff vs. failure models of psychiatric conditions, arguing that this pattern is actually common sense - most multifactorial problems naturally combine both types. He illustrates this with everyday examples like poverty (which can result from failures like poor health or tradeoffs like choosing to be a starving artist), relationships, and even physical illnesses like cancer. Scott concludes he has 'dissolved' what he previously saw as a mysterious fact about psychiatric conditions into something obvious: complex multidimensional problems will naturally have multiple causes falling into both the 'by choice' and 'not by choice' categories. Shorter summary
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