Scott Alexander examines the surprisingly broad effects of GLP-1 drugs like Ozempic, exploring their mechanisms and speculating on why they seem to impact so many different conditions. Longer summary

Scott Alexander explores the wide-ranging effects of GLP-1 receptor agonist medications like Ozempic, which are approved for diabetes and obesity but show promise for many other conditions. He delves into the mechanisms behind their effects on diabetes, weight loss, and addiction, speculating on why these drugs seem to have such broad impacts. The post discusses how GLP-1 drugs work in the brain to reduce hunger and dampen reward systems, potentially explaining their effects on addiction. Scott also touches on their anti-inflammatory properties and potential benefits for neurodegenerative diseases, while cautioning that some reported effects may not replicate. Shorter summary

A review of 'The Family That Couldn't Sleep' by D. T. Max, discussing its exploration of prion diseases and their impact, with updated perspectives on the book's conclusions. Longer summary

This review discusses 'The Family That Couldn't Sleep' by D. T. Max, a book about prion diseases published in 2006. The review covers the book's exploration of various prion diseases, including fatal familial insomnia, kuru, mad cow disease, and chronic wasting disease. It highlights the book's focus on the historical, scientific, and cultural aspects of these diseases, as well as the key figures involved in prion research. The reviewer also provides updated information and critiques some of the book's conclusions in light of more recent research. Shorter summary