Scott announces the results of the 2025 ACX Grants round, awarding $1.5 million to 42 projects out of 654 applications, covering areas from genetic engineering and disease prevention to AI safety and educational reform. Longer summary

Scott Alexander announces the results of the 2025 ACX Grants program, which received 654 applications and funded 42 projects across diverse areas including global health, AI safety, metascience, animal welfare, and development economics. The grants range from $5,000 to $150,000 and support initiatives like genetically engineered nutritious corn, screwworm eradication, lead-acid battery recycling programs, organ donation improvement, AI bias research, and various biosecurity and pandemic prevention projects. Scott thanks the funders, Manifund team, and numerous expert evaluators who helped assess applications, and notes that some projects remain in stealth mode. The post concludes with extensive credits to contributors and mentions that the next grants round will likely occur in late 2026 or early 2027. Shorter summary

Scott Alexander and 1DaySooner outline potential positive health policy initiatives that could emerge under three key Trump administration health appointees: Jim O'Neill, Marty Makary, and Jay Bhattacharya. Longer summary

This post discusses potential health policy proposals under a hypothetical second Trump administration, focusing on three key appointees and their possible initiatives. The piece examines Jim O'Neill as Deputy Secretary of HHS, highlighting his potential work on organ donation compensation and longevity research; Marty Makary as FDA Commissioner, discussing FDA transparency and regulatory improvements; and Jay Bhattacharya as NIH Director, exploring research funding reforms and challenge trials. Written in collaboration with 1DaySooner, the post specifically focuses on optimistic scenarios that could emerge from these appointments. Shorter summary

Scott Alexander presents a satirical account of a Bay Area house party, showcasing absurd startup ideas and intellectual discussions that parody Silicon Valley culture. Longer summary

Scott Alexander describes another fictional Bay Area house party, filled with eccentric characters pitching outlandish startup ideas and discussing bizarre theories. The narrative weaves through conversations about AI-generated myths, financial communication through rap, the future of human thought in the age of AI, Wikipedia editing dilemmas, extreme urban planning ideas, and ethical considerations in organ donation. The story satirizes Silicon Valley culture, startup mentality, and various intellectual subcultures. Shorter summary