Scott Alexander explains how the vastly higher doses taken by recreational drug users compared to psychiatric patients lead to misconceptions about drug safety in clinical settings. Longer summary

Scott Alexander discusses how recreational drug users consume substantially higher doses of drugs compared to psychiatric patients, which leads to misconceptions about drug safety in clinical settings. He provides examples of ketamine and amphetamines to illustrate this point. For ketamine, psychiatric doses are around 280 mg/month, while recreational users consume about 90,000 mg/month. Similarly, for amphetamines, Adderall patients typically take 20 mg daily, whereas methamphetamine addicts use the equivalent of 1000 mg oral amphetamine daily. Scott argues that many concerns about drug side effects in clinical settings are based on studies of recreational users, and that these concerns may not apply to patients taking much lower doses under medical supervision. Shorter summary

Scott Alexander examines the development and effectiveness of vilazodone and vortioxetine, two antidepressants designed to work faster and better than SSRIs, but which ultimately failed to live up to expectations. Longer summary

Scott Alexander discusses the development and effectiveness of two antidepressants, vilazodone and vortioxetine, which were designed to combine SSRI effects with 5-HT1A partial agonism. He explains the theoretical basis for their development, involving the role of presynaptic 5-HT1A autoreceptors in delaying SSRI effectiveness. The post then evaluates the clinical performance of these drugs, finding that despite their innovative design, they don't significantly outperform older antidepressants in efficacy, onset speed, or side effect profile. Scott expresses confusion about the theoretical underpinnings of these drugs and why pharmaceutical companies invested so heavily in their development. Shorter summary

Scott Alexander presents survey results on people's satisfaction with mental health care, showing varied preferences across different types of therapy and conditions. Longer summary

Scott Alexander analyzes the results of the SSC survey regarding people's experiences with mental health care. The post presents various graphs showing satisfaction ratings for different types of therapy, medication, and mental health issues. Key findings include an average rating of 5.7/10 for both psychotherapy and medication, higher satisfaction with therapy from books compared to in-person or online therapy, and varying preferences for medication vs. therapy depending on the mental health condition. The author emphasizes that the results are exploratory and subject to biases. Shorter summary

Scott Alexander presents results from an SSC Survey on SSRI usage, covering effectiveness, side effects, and discontinuation experiences among 2,090 users. Longer summary

Scott Alexander presents the results of an SSC Survey on SSRI usage, covering their effectiveness, side effects, and discontinuation experiences. The survey included 2,090 SSRI users and explored various aspects of SSRI use. Key findings include: most users found SSRIs helpful, with Lexapro rated highest and Paxil lowest; SSRIs seemed more effective for anxiety than depression; 70% of users experienced side effects, with sexual difficulties being most common; 15% reported persistent side effects after discontinuation; and discontinuation difficulty varied among different SSRIs, with Prozac being easiest to discontinue. The survey largely confirmed existing psychiatric consensus, with the high rate of persistent side effects being the main surprise. Shorter summary

Scott Alexander outlines 18 preregistered investigations for the 2019 SSC survey, covering topics from psychiatric medication effects to birth order influences. Longer summary

Scott Alexander preregisters 18 investigations for the 2019 Slate Star Codex survey. These investigations cover a wide range of topics including psychiatric medication effects, social class perceptions, life history strategies, gender bias, imposter syndrome, and birth order effects. The post begins by urging readers to take the survey before reading further to avoid bias. Each investigation is briefly described, often including the reasoning behind it or the specific analysis method to be used. The investigations touch on fields such as psychology, sociology, psychiatry, and genetics, reflecting the diverse interests of the blog's audience. Shorter summary

Scott Alexander offers various strategies for obtaining affordable mental health care and medication in the US, including discount programs, therapy alternatives, and supplement options. Longer summary

This post provides detailed advice on how to access mental health care and medication on a budget in the US. Scott outlines various strategies for obtaining prescription medications at lower costs, including using discount websites, pill splitting, and patient assistance programs. He also discusses affordable therapy options and supplement alternatives to prescription drugs. The post is aimed at those who don't qualify for government assistance and includes both legal and potentially legal methods. Scott emphasizes that this is not medical advice and should be used at one's own risk. Shorter summary

Scott Alexander reviews the psychiatric medication information site crazymeds.us, praising its quality but explaining why he can't recommend it to patients due to potential offense. Longer summary

Scott Alexander discusses the website crazymeds.us, praising its accurate, readable, and humorous descriptions of psychiatric medications. He compares it favorably to more official sources like drugs.com, which often provide overwhelming and unhelpful information. Despite its quality, Scott explains why he can't recommend it to patients, citing concerns about its potentially offensive name and content. He explores the concept of 'negative selection' in medicine and how it affects his decision-making. The post concludes by reflecting on the trade-offs between effectiveness and political correctness in medical communication. Shorter summary