How to explore Scott Alexander's work and his 1500+ blog posts? This unaffiliated fan website lets you sort and search through the whole codex. Enjoy!

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May 15, 2024
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Profile: The Far Out Initiative

28 min • 4,196 words • 903 comments • 283 likes • podcast (25 min)
The post explores the Far Out Initiative's goal to eliminate suffering through biotechnology, inspired by a pain-free woman and David Pearce's philosophy. Longer summary
This post discusses the Far Out Initiative, a project aimed at eliminating suffering through biotechnology. It begins by introducing Jo Cameron, a woman genetically incapable of feeling pain or anxiety, and explores the philosophical implications of her condition. The post then delves into David Pearce's suffering abolitionism philosophy and his practical approaches to ending suffering. Finally, it describes the Far Out Initiative's current efforts, led by Marcin Kowrygo, to create suffering-free animals through genetic engineering and potentially extend this to humans in the future. Shorter summary
Apr 16, 2024
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Updates on Lumina Probiotic

11 min • 1,699 words • 167 comments • 152 likes • podcast (11 min)
Scott Alexander updates on Lumina probiotic, discussing FDA trials, effectiveness, potential risks, and his nuanced stance on the product. Longer summary
Scott Alexander provides updates on Lumina, a genetically modified anti-tooth-decay bacterium. He clarifies information about FDA testing, discusses rat trial results, reports on recent colonization studies, addresses potential side effects, and shares some anecdotal results. Scott also explains his stance on Lumina, emphasizing that while he sees potential benefits, he doesn't fully endorse it and acknowledges the uncertainties and risks involved. Shorter summary
Dec 07, 2023
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Defying Cavity: Lantern Bioworks FAQ

20 min • 3,074 words • 417 comments • 222 likes • podcast (18 min)
Scott Alexander reviews Lantern Bioworks' Lumina, a genetically modified bacterium designed to prevent tooth decay, discussing its science, safety, and commercialization plans. Longer summary
Scott Alexander discusses Lantern Bioworks' new product, Lumina, a genetically modified bacterium designed to prevent tooth decay. The post covers the science behind the product, its origins, usage, potential risks, and the company's plans for commercialization. Scott explains the genetic modifications made to the bacterium, addresses safety concerns, and discusses the regulatory path Lantern is pursuing. The article also touches on the product's pricing strategy and availability. Shorter summary
Mar 02, 2021
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Shilling For Big Mitochondria

16 min • 2,465 words • 292 comments • 132 likes • podcast (18 min)
Scott Alexander explores the history and mechanism of DNP, a dangerous but effective weight-loss drug, and discusses recent developments in safer mitochondrial uncoupling agents. Longer summary
Scott Alexander discusses 2,4-dinitrophenol (DNP), a controversial and dangerous weight-loss drug that works by uncoupling mitochondria. He traces its history from the 1930s to modern times, explaining its effectiveness and severe side effects. The post then explores recent developments in mitochondrial uncoupling research, including potential safer alternatives and therapeutic applications beyond weight loss. Shorter summary