How to explore Scott Alexander's work and his 1500+ blog posts? This unaffiliated fan website lets you sort and search through the whole codex. Enjoy!

See also Top Posts and All Tags.

Minutes:
Blog:
Year:
Show all filters
2 posts found
Dec 08, 2022
acx
9 min 1,161 words 115 comments 87 likes podcast (9 min)
Scott explores GABA-A receptor subunits, their effects, and how various drugs interact with them, discussing potential for more selective drug development. Longer summary
This post explores GABA-A receptor subunits and their role in psychiatric drugs and supplements. It explains the structure of GABA-A receptors, focusing on the alpha subunits and their associated effects. The post discusses how different drugs like benzodiazepines and zolpidem (Ambien) interact with these subunits, and mentions attempts to create more selective drugs. It also touches on the role of GABA receptors in alcohol's effects and the classification of Z-drugs. The author includes personal experiences with supplements claiming to have selective GABA modulation. Shorter summary
Nov 07, 2018
ssc
7 min 952 words 181 comments podcast (8 min)
Scott updates his stance on marijuana legalization based on new data showing increased traffic accidents, but remains uncertain due to the complexity of the issue. Longer summary
Scott Alexander revisits his previous analysis of marijuana legalization, focusing on its effects on road traffic accidents. New studies show a 5-6% increase in car crashes and fatalities in states with legalized marijuana, contradicting his earlier prediction of a decrease. This shifts his assessment from slightly positive to slightly negative. However, he emphasizes the weakness of the math and the many assumptions involved. The post also considers other factors like people's enjoyment of marijuana, its comparison to alcohol and SSRIs, potential cancer risks, and tax implications. Scott concludes without a firm position, acknowledging the complexity of the issue. Shorter summary