A guest post defending the amyloid hypothesis of Alzheimer's disease, explaining why amyloid is likely the root cause despite recent criticism and discussing why early treatments have only been partially effective. Longer summary

David Schneider-Joseph presents a detailed defense of the amyloid hypothesis of Alzheimer's disease, which states that the disease is caused by accumulation of amyloid-β peptide. He explains the ATN model (amyloid → tau → neurodegeneration) and provides extensive evidence from genetics, clinical studies, and animal models. The post addresses various criticisms of the hypothesis, including the recent research fraud controversy and apparent failures of early treatments. The author explains why current treatments have only achieved about 30% efficacy and predicts that future treatments targeting amyloid earlier and more effectively could achieve much better results. Shorter summary

A compilation of 50 diverse news items and links from September 2024, covering topics from politics and economics to science and technology. Longer summary

This post is a compilation of 50 diverse links and news items from September 2024. It covers a wide range of topics including politics, science, technology, economics, and social issues. Some notable items include discussions on kidney donation compensation, personality genetics, fertility rates in Israel, drug decriminalization in Oregon, AI regulation in California, and various political and economic analyses. The post also includes commentary on recent studies, books, and social phenomena. Shorter summary