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2 posts found
Jul 10, 2018
ssc
38 min 5,247 words 154 comments podcast (36 min)
Scott Alexander examines melatonin's effects, proper dosage, and uses for sleep disorders and circadian rhythm issues, emphasizing its dual role as a hypnotic and chronobiotic. Longer summary
Scott Alexander provides an in-depth analysis of melatonin, its effects, and proper usage. He explains that melatonin functions as both a hypnotic (inducing sleep) and a chronobiotic (shifting circadian rhythms). The post covers optimal dosing (0.3 mg, much lower than commonly available doses), use in treating circadian rhythm disorders, jet lag, and potential connections to other psychiatric conditions like seasonal affective disorder and depression. Scott also discusses personal experiences with melatonin, including its tendency to cause early waking and vivid dreams in some people. Shorter summary
Feb 16, 2014
ssc
24 min 3,284 words 40 comments
Scott Alexander reports on a survey of nootropics users, finding mixed results for various substances and discussing methodological challenges in assessing their effectiveness. Longer summary
Scott Alexander presents the results of a survey on nootropics, substances claimed to improve mental functioning. The survey, taken by 162 respondents from online nootropics communities, asked about experiences with 28 different substances. Key findings include: caffeine and modafinil were rated most effective; some newer substances like phenylpiracetam and coluracetam showed promise; traditional medicines had mixed results; dose-response relationships were mostly inconclusive except for high-dose vitamin D; and there were unexpected correlations between effects of different substances. Scott discusses limitations of the survey and plans for future iterations. Shorter summary