Scott Alexander examines and expresses skepticism about a theory that attributes high-dose melatonin supplements to patent avoidance, while reflecting on the challenges of evaluating such claims. Longer summary

Scott Alexander discusses a theory about why melatonin supplements are often sold in doses much higher than recommended. The theory, proposed by Dr. Richard Wurtman, suggests that supplement manufacturers used higher doses to avoid paying royalties on a patent for lower doses. Scott expresses skepticism about this explanation, citing reasons such as the unusualness of patenting only up to a certain dose and the fact that many supplements are sold in high doses. He also notes that some companies do sell melatonin at the recommended dose without legal issues. Scott reflects on the challenges of evaluating such claims, balancing expert knowledge against rational skepticism. An update clarifies that the patent likely influenced initial supplement production but has since expired, though high-dose traditions persist. Shorter summary

Scott Alexander examines melatonin's effects, proper dosage, and uses for sleep disorders and circadian rhythm issues, emphasizing its dual role as a hypnotic and chronobiotic. Longer summary

Scott Alexander provides an in-depth analysis of melatonin, its effects, and proper usage. He explains that melatonin functions as both a hypnotic (inducing sleep) and a chronobiotic (shifting circadian rhythms). The post covers optimal dosing (0.3 mg, much lower than commonly available doses), use in treating circadian rhythm disorders, jet lag, and potential connections to other psychiatric conditions like seasonal affective disorder and depression. Scott also discusses personal experiences with melatonin, including its tendency to cause early waking and vivid dreams in some people. Shorter summary

Scott Alexander critiques the medical system's preference for expensive prescription sleep aids like Ramelteon over cheaper alternatives like melatonin, while sharing interesting facts about melatonin's uses. Longer summary

Scott Alexander discusses Ramelteon, a prescription sleep medication that mimics melatonin. He compares it to over-the-counter melatonin, highlighting the absurdity of the medical system that creates expensive prescription drugs when cheaper, effective alternatives exist. The post criticizes the pharmaceutical industry and medical practice for overlooking simple solutions like melatonin. Scott also shares interesting facts about melatonin, including its potential uses beyond sleep aid. Shorter summary

Scott Alexander discusses his brain's arbitrary division of sleep into 'sleep mode' and 'nap mode', which interferes with establishing a normal sleep schedule, and asks for others' experiences and solutions. Longer summary

Scott Alexander describes a peculiar sleep pattern he experiences, where his brain distinguishes between 'sleep mode' and 'nap mode' based on the time he tries to fall asleep. Sleep attempts after 1 AM result in longer, groggier sleep periods, while attempts before 1 AM lead to shorter, more refreshing naps. This pattern interferes with his attempts to establish a normal sleep schedule and is incompatible with standard work hours. He shares his experiences with various sleep aids and techniques, noting their limited effectiveness in addressing this specific issue. Scott asks if others have experienced similar patterns and if they've found solutions. Shorter summary