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drug mechanisms (3)
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study critique (270)
book review (221)
AI (112)
economics (105)
effective altruism (105)
education (93)
creative writing (91)
debate (89)
forecasting (89)
politics (89)
prediction markets (88)
science (85)
AI safety (79)
media criticism (76)
neuroscience (76)
rationality (76)
psychiatry (73)
psychology (72)
mental health (69)
highlights from the comments (68)
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3 posts
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highlights from the comments (68) drug pricing (11) tolerance (5) Zulresso (3) postpartum depression (3) drug mechanisms (3) hormone therapy (3) progesterone (2) Zuranolone (2)

Highlights From The Comments On Zulresso

Scott Alexander highlights and responds to expert comments on his previous posts about Zulresso and Zuranolone, covering various aspects of these drugs and related topics.

acx
Mar 16, 2022 1,804 words 37 likes 16 comments Listen · 14 min Read Read
medical research (52) FDA (37) healthcare costs (22) postpartum depression (3) Zulresso (3) drug mechanisms (3) hormone therapy (3) progesterone (2)

Progesterone Megadoses Might Be A Cheap Zulresso Substitute

Scott Alexander proposes using high-dose oral progesterone as a potential low-cost alternative to Zulresso for treating postpartum depression, based on pharmacological research.

acx
Mar 10, 2022 701 words 53 likes 84 comments Listen · 8 min Read Read
psychopharmacology (7) drug addiction (5) drug mechanisms (3) anxiety treatment (2) phenibut (2)

Know Your Gabapentinoids

Scott Alexander compares three gabapentinoid drugs (gabapentin, pregabalin, and phenibut), exploring their effects, mechanisms, and the mysteries surrounding their differing efficacies despite chemical similarities.

ssc
Jul 18, 2019 2,297 words 0 likes 101 comments Listen · 17 min Read Read
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