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2 posts found
Mar 16, 2022
acx
13 min 1,804 words 17 comments 37 likes podcast (14 min)
Scott Alexander highlights and responds to expert comments on his previous posts about Zulresso and Zuranolone, covering various aspects of these drugs and related topics. Longer summary
Scott Alexander summarizes and responds to comments on his previous posts about Zulresso and Zuranolone. The post covers various topics including drug pricing, mechanism details of GABA receptors, etymology of drug names, tolerance development, progesterone's effects, and personal experiences with progesterone. Scott expresses appreciation for the expertise of his commenters, particularly in biomedical topics, and acknowledges learning new information from them. Shorter summary
Mar 10, 2022
acx
5 min 693 words 88 comments 52 likes podcast (8 min)
Scott Alexander proposes using high-dose oral progesterone as a potential low-cost alternative to Zulresso for treating postpartum depression, based on pharmacological research. Longer summary
Scott Alexander explores the possibility of using high-dose progesterone as a cheaper alternative to Zulresso for treating postpartum depression. He explains that Zulresso is a metabolite of progesterone and presents research suggesting that a specific regimen of oral progesterone could potentially mimic the effects of Zulresso. The post discusses the pharmacokinetics, dosing schedule, and potential cost savings, with progesterone treatment costing only about $11 compared to Zulresso's $35,000. Scott acknowledges potential obstacles in implementation but hopes researchers will investigate this approach further. Shorter summary