Scott Alexander examines a review of a paper on serotonin receptors, discussing prediction error, suffering, and the effects of different serotonin receptor activations on problem-solving approaches and psychedelic experiences.

Scott Alexander examines the compatibility of enlightenment with sex scandals, using recent Buddhist teacher scandals as a starting point for broader questions about consciousness and social conditioning.

Scott Alexander investigates the prevalence of Hallucinogen Persisting Perceptual Disorder (HPPD) and explores potential connections between perception, cognition, and belief in supernatural phenomena.

Scott Alexander reviews 'The Electric Kool-Aid Acid Test', examining Ken Kesey's LSD-fueled counterculture movement and its lasting impact.

Scott Alexander presents a case for skepticism about psychedelic therapy in psychiatry, outlining seven points of concern while still supporting further research.

Scott Alexander explores Hallucinogen Persisting Perception Disorder (HPPD) and other conditions where drugs cause permanent effects, discussing potential mechanisms and their implications.

Scott Alexander presents results from a survey of 850 people rating various nootropics, showing a range of perceived effectiveness and exploring addiction potential for some substances.

Scott Alexander speculates about mental feedback loops, their relation to various disorders, and how increased self-awareness might accidentally worsen them.