Scott shares various interesting links and news items from January 2025, covering topics from AI development and politics to historical curiosities and economic trends. Longer summary

This links post covers a wide array of topics from January 2025, with Scott providing commentary and analysis on each. The links include discussions about running for Congress, AI development and safety, dating advice, psychiatric diagnoses, and various economic and technological developments. Scott often adds his own insights and sometimes skepticism to the claims being discussed. The post also includes several historical curiosities and social observations, maintaining a mix of serious analysis and lighter interesting facts. Shorter summary

Scott Alexander examines Zulresso and Zuranolone, two neurosteroid drugs for postpartum depression, discussing their efficacy, challenges, and potential future applications. Longer summary

Scott Alexander discusses Zulresso (allopregnanolone) and Zuranolone, two related drugs for treating postpartum depression. He explains their mechanisms, efficacy, and the challenges in their development and usage. The post covers the history of allopregnanolone research, its connection to GABA and hormones, clinical trials, and potential future applications. Scott also discusses the high cost of Zulresso, its limited availability, and the mixed results of Zuranolone in treating regular depression and anxiety. The post ends with predictions about the future of these drugs and related research. Shorter summary

Scott Alexander reviews comments on his posts about aducanumab and the FDA, acknowledging some mistakes while defending his overall critique of FDA conservatism. Longer summary

Scott Alexander reviews comments on his recent posts about aducanumab and the FDA. He acknowledges some mistakes in his original post, but defends his overall critique of the FDA as overly conservative. The comments cover various aspects of drug approval, including the aducanumab controversy, surrogate endpoints, the FDA's impact on small biotech companies, and comparisons to other regulatory systems. Scott reflects on how to improve his fact-checking process while still writing passionate pieces. Shorter summary

Scott Alexander shares a diverse collection of interesting links on topics ranging from science and politics to economics and culture, with brief commentary on many items. Longer summary

This post is a collection of links to various interesting articles, studies, and news items. It covers a wide range of topics including scientific discoveries, political events, economic trends, technological advancements, and cultural phenomena. Scott Alexander provides brief commentary on many of the links, often adding context or his own thoughts. The tone is informative and occasionally humorous, with a focus on sharing intriguing information across diverse fields. Shorter summary