Scott Alexander examines the historical link between gout and achievement, ultimately finding the evidence unconvincing despite some intriguing connections.

Scott Alexander attempts to replicate a study linking beef jerky consumption to manic episodes in bipolar disorder, finding no significant relationship in his analysis of SSC survey data.

Scott reviews a paper proposing a computational model of mood and emotions based on predictive processing, discussing its implications for understanding mood disorders.

Scott proposes a speculative theory of depression as pathologically low confidence in neural predictions within the predictive processing framework, explaining how this could account for various depressive symptoms.