Scott Alexander suggests that studying human fetishes could provide insights into AI alignment challenges, particularly regarding generalization and interpretability. Longer summary

Scott Alexander explores the idea that fetish research might help understand AI alignment. He draws parallels between evolution's 'alignment' of humans towards reproduction and our attempts to align AI with human values. The post discusses how fetishes represent failures in evolution's alignment strategy, similar to potential AI alignment failures. Scott suggests that studying how humans develop fetishes could provide insights into how AIs might misgeneralize or misalign from intended goals. He proposes several speculative explanations for common fetishes and discusses how these might relate to AI alignment challenges, particularly in terms of generalization and interpretability problems. Shorter summary

Scott Alexander investigates the unexpectedly high prevalence of joint hypermobility in transgender individuals, exploring various theories and presenting survey data on the phenomenon. Longer summary

Scott Alexander explores the puzzling connection between transgender identity and hypermobile joints, particularly Ehlers-Danlos syndrome (EDS). He presents four theories to explain this correlation: 1) It's a spurious result due to 'Instagrammable' conditions clustering together, 2) Estrogen effects on joints in trans women, 3) Genetic link between gender divergence and joint issues, and 4) Autism as a shared causative factor. Scott favors a theory linking proprioception issues to different reasoning styles, potentially leading to both autism and transgender identity. He presents data from his own survey showing higher rates of joint issues in trans respondents, though with some limitations. The post concludes with plans for further investigation in future surveys. Shorter summary

Scott explores the puzzling relationship between congenital blindness, schizophrenia, and autism, discussing potential explanations and the need for further research. Longer summary

Scott Alexander discusses the intriguing psychiatric trivia that congenitally blind people never develop schizophrenia, but are 50 times more likely to be diagnosed with autism. He explores this in the context of the diametrical model of autism vs. schizophrenia, which suggests these conditions are opposites in many ways. Scott speculates on possible explanations, including the idea that blindness might shift certain neural hyperparameters towards the autism end of a spectrum. He acknowledges the complexity of the issue and the need for further research, mentioning studies on sensory deprivation and its effects on both conditions. Shorter summary

Scott Alexander examines whether psychiatric conditions result from evolutionary failures or tradeoffs, proposing that most disorders involve a combination of both. Longer summary

Scott Alexander explores the nature of psychiatric conditions, discussing whether they result from evolutionary failures or tradeoffs. He presents evidence for both hypotheses, noting that recent research favors the failure hypothesis. However, he argues that some conditions likely involve both failures and tradeoffs. He uses analogies from justice systems and nuclear war scenarios to illustrate how failures and tradeoffs can interact. The post concludes by suggesting that most psychiatric disorders exist on a spectrum from mostly-tradeoff to mostly-failure, and critiques the neurodiversity movement's blanket statements about conditions like autism. Shorter summary

Scott Alexander examines taxometrics in psychiatry, finding that most mental health conditions are dimensional rather than categorical, and discusses the implications for diagnosis and treatment. Longer summary

Scott Alexander explores the concept of taxometrics, which studies whether psychiatric conditions are categorical or dimensional. He explains the difference between categorical distinctions (like humans vs. rabbits) and dimensional variations (like height), and discusses how taxometric methods attempt to determine which psychiatric conditions fall into each category. The post then reviews recent meta-analyses suggesting that most psychiatric conditions are dimensional rather than categorical, contrary to some expectations. Scott reflects on the implications of this for psychiatric diagnosis and treatment, suggesting a move away from binary thinking about mental health conditions. Shorter summary

Scott Alexander analyzes survey data to investigate whether assortative mating among highly analytical people increases autism risk in their children, finding no significant evidence for this hypothesis. Longer summary

Scott Alexander investigates whether assortative mating among highly analytical people in Silicon Valley increases the risk of autism in their children. He uses data from the 2020 Slate Star Codex survey, which included 8,043 respondents from highly analytical backgrounds. The study found that while the sample had higher rates of autism (4-8%) than the general population (2.5-5%), there was no significant increase in autism rates among children of couples where both partners were highly analytical. The autism rate for children in the sample was 3.7-5.2%, with only 0.6% having severe autism. Scott concludes that while the study has limitations, it provides evidence against strong versions of the assortative mating hypothesis for autism risk. Shorter summary

Scott Alexander argues that psychiatric diagnoses, while imperfect, are useful tools despite potentially combining multiple conditions with different causes. Longer summary

Scott Alexander discusses the criticism that psychiatric conditions like autism or depression are not unitary categories but rather collections of different conditions with different causes. He argues that this view, while correct, is not as revolutionary as some think and doesn't invalidate the usefulness of these diagnoses. Scott compares psychiatric conditions to medical conditions like pulmonary edema or stroke, which can have multiple causes but are still useful diagnostic categories. He suggests that psychiatric disorders might ultimately be understood as computational conditions, with various biological, psychological, and environmental factors affecting the brain's computational parameters. The post emphasizes that while research into subtypes of conditions like depression hasn't been very productive, current psychiatric diagnoses remain the most useful tool available, despite their limitations. Shorter summary

Scott Alexander examines the paradoxical relationship between autism and intelligence, discussing genetic and environmental factors, and proposing explanatory models for the observed lower IQ in autistic individuals despite genetic links to higher intelligence. Longer summary

Scott Alexander explores the paradoxical relationship between autism and intelligence. While genetic studies show a link between autism risk genes and high IQ, autistic individuals generally have lower intelligence than neurotypical controls. The post discusses three main causes of autism: common 'familial' genes that increase IQ, rare 'de novo' mutations that are often detrimental, and non-genetic factors like obstetric complications. Scott examines various studies and proposes that even after adjusting for mutations and environmental factors, autism still seems to decrease IQ. He introduces a 'tower-vs-foundation' model to explain this phenomenon, where intelligence needs a strong foundation to support it, and an imbalance can lead to autism. The post concludes with a list of findings and their associated confidence levels. Shorter summary

The post explores the diametrical model of autism and schizophrenia, suggesting they represent opposite ends of a spectrum from mechanistic to mentalistic cognition. Longer summary

This post discusses the diametrical model of autism and schizophrenia, which posits that these conditions are opposite ends of a spectrum from overly mechanistic to overly mentalistic cognition. The author explains how this theory accounts for observed similarities and differences between autism and schizophrenia, including genetic, neurological, and behavioral factors. The post explores the concepts of schizotypy and high-functioning autism, and how they relate to this model. It also touches on gender differences, mutational load, and how this theory might explain certain cognitive strengths and weaknesses associated with each condition. The author acknowledges that while there's limited scientific evidence for this model, it provides an interesting framework for understanding these complex disorders. Shorter summary

Scott Alexander reports on weak correlations and inconclusive results from the latest SSC survey on optical illusions and visual perception. Longer summary

Scott Alexander discusses the results of the latest SSC survey, focusing on optical illusions and visual riddles. He admits to being unable to expand on or strengthen his previous findings from 'Why Are Transgender People Immune To Optical Illusions' and 'Can We Link Perception And Cognition?'. While he weakly replicated some previous results, the correlations were too low to be exciting. He found minimal internal structure in the results, with different versions of the same illusion showing low correlation. The post also briefly mentions some pre-registered investigations that yielded uninteresting or negative results, including studies on political conflict theory, autism and categorization responses, and ADHD and ambition. Shorter summary

Scott Alexander preregisters hypotheses for the 2018 SSC Survey, planning to explore relationships between perception, cognition, personality, and demographics. Longer summary

Scott Alexander preregisters his hypotheses for the 2018 SSC Survey. He plans to investigate various relationships between perception, cognition, personality traits, and demographic factors. Key areas of focus include replicating previous findings on perception and cognition, exploring concepts like 'first sight and second thoughts' and 'ambiguity tolerance', investigating birth order effects, and examining correlations with autism, political views, and sexual harassment. He also plans to follow up on a previous AI risk persuasion experiment. Shorter summary

Scott proposes a speculative theory of depression as pathologically low confidence in neural predictions within the predictive processing framework, explaining how this could account for various depressive symptoms. Longer summary

This post explores a potential theory of depression within the predictive processing (PP) framework. Scott starts by noting the lack of a compelling PP account for depression, then proposes that depression might be a state of pathologically low confidence in neural predictions. He explains how this could account for various symptoms of depression, including perceptual changes, psychomotor retardation, and lack of motivation. The post then speculates on why low confidence might cause sadness, suggesting that emotions could be a way of globally adjusting confidence levels based on past success or failure. Scott acknowledges the speculative nature of these ideas and some potential problems with the theory. Shorter summary

Scott Alexander examines the conflict between predictive processing theory and evolutionary psychology claims about innate knowledge, questioning how genes could directly encode complex preferences. Longer summary

Scott Alexander explores the tension between predictive processing (PP) theory and evolutionary psychology claims about innate knowledge. He argues that while PP can accommodate some genetic influences on cognition, it struggles to explain how genes could directly encode high-level concepts like 'attraction to large breasts.' The post questions how such specific preferences could be genetically programmed given the limited number of genes humans have. Scott acknowledges that instincts clearly exist in animals, but suggests that even seemingly innate traits like gender identity may involve some level of inference. He proposes a heuristic for evaluating evolutionary psychology claims, recommending skepticism towards ideas that genes can directly manipulate high-level concepts unless there's a compelling evolutionary reason. Shorter summary

Scott Alexander reviews 'Surfing Uncertainty' by Andy Clark, exploring the predictive processing model of brain function and its wide-ranging explanatory power. Longer summary

Scott Alexander reviews the book 'Surfing Uncertainty' by Andy Clark, which explains the predictive processing model of how the brain works. This model posits that the brain is constantly making predictions about sensory input and updating its models based on prediction errors. Scott explores how this theory can explain various phenomena like attention, imagination, learning, motor behavior, and even psychiatric conditions like autism and schizophrenia. He finds the model compelling and potentially explanatory for a wide range of cognitive and perceptual processes. Shorter summary

Scott Alexander hypothesizes a link between transgender identity, optical illusions, and NMDA receptor function, based on survey data and existing research on schizophrenia and autism. Longer summary

Scott Alexander explores a potential link between transgender identity, optical illusions, and NMDA receptor function in the brain. He presents survey data suggesting that transgender individuals, like those with schizophrenia and autism, are less susceptible to certain optical illusions. He hypothesizes that this might be related to NMDA receptor hypofunction, which is also associated with dissociation, a common experience among transgender people. The post explores how estrogen, which enhances NMDA function, alleviates dissociation in trans women. Scott connects these findings to broader research on NMDA receptors in schizophrenia and autism, noting the higher prevalence of these conditions in transgender populations. The post concludes with several caveats and suggestions for future research to validate these speculative connections. Shorter summary

The post explores how neurotypical social interactions often involve indirect communication, which can be confusing for autistic individuals, and suggests that conversations may be deliberately designed to be unpredictable. Longer summary

The post discusses the complexity of social interactions, particularly focusing on how neurotypical people often ask indirect questions to initiate conversations or join activities. It explains how this can lead to miscommunication with autistic individuals who may interpret these questions literally. The author explores the concept of 'plausible deniability' in social interactions, where people deliberately skirt the border of incomprehensibility to allow for graceful rejections. The post concludes by suggesting that ordinary conversations might be deliberately designed to be difficult to predict, making them particularly challenging for those who struggle with social cues. Shorter summary

Scott Alexander examines a theory linking autism and schizophrenia to human self-domestication, initially dismissing it before reconsidering its merits in light of Williams Syndrome. Longer summary

Scott Alexander discusses a theory suggesting that autism and schizophrenia are anomalies in human self-domestication. He initially dismisses the theory, pointing out inconsistencies and over-reaching comparisons. However, he then considers Williams Syndrome, which appears to fit the 'hyperdomestication' model better. Scott concludes that while autism and schizophrenia may not be exact opposites of domestication, they likely involve a biological system determining trust and sociability, which is linked to embryological development. He suggests that an embryological approach might be more fruitful in studying these conditions. Shorter summary

The post explores how Bayesian processes in the brain might explain perception and various mental disorders, linking neurotransmitters to different aspects of Bayesian reasoning. Longer summary

This post explores the application of Bayes' Theorem to neuroscience and psychiatry. It discusses how the brain might use Bayesian processes for perception and cognition, and how disruptions in these processes could explain various mental disorders. The author first explains Bayes' Theorem and its relevance to perception, then delves into a neuroscientific model that links neurotransmitters to different aspects of Bayesian processing. The post then applies this model to explain phenomena in schizophrenia, psychedelic experiences, and autism. The author concludes by pointing out some limitations and inconsistencies in the model, while still appreciating its potential as a high-level framework for understanding brain function and mental disorders. Shorter summary

Scott Alexander analyzes 2D:4D ratio data from LW/SSC surveys, finding unexpected correlations with feminism and masculinity, despite failing to replicate basic gender differences in digit ratios. Longer summary

Scott Alexander discusses his analysis of the 2D:4D ratio (length of index finger divided by length of ring finger) and its correlations with psychological traits, using data from the Less Wrong and Slate Star Codex surveys. The study aimed to explore connections between digit ratio, gender, and various traits like feminism and autism. Despite failing to replicate the basic finding of men having lower digit ratios than women, the study found unexpected correlations between digit ratio and opinion of feminism in men, and between digit ratio and masculinity in women. Scott expresses confusion about these results, noting inconsistencies with previous research and unexpected patterns in the data. He concludes that while the study was messy, it managed to find clear signals in unexpected places, though he remains uncertain about the implications of these findings. Shorter summary

Scott Alexander critiques the autism rights movement's opposition to curing autism, arguing that severe cases cause immense suffering that justifies continued research into cures. Longer summary

Scott Alexander discusses the autism rights movement and their opposition to curing autism. While supporting most of their work, he disagrees with the stance against cures. He argues that severe autism causes immense suffering that cannot be alleviated solely through better treatment, and that research into cures should continue. He acknowledges the benefits autism can bring, but believes the costs outweigh them for many individuals. The post examines outcomes for autistic adults, issues with institutionalization, and ethical considerations around curing or preventing autism. Shorter summary

The post analyzes survey data to examine if effective altruism attracts people with mental disorders, finding slightly higher rates of autism but no evidence of unusual self-hate or scrupulosity. Longer summary

This post examines the theory that effective altruism (EA) attracts people with mental disorders. The author analyzes data from a Less Wrong survey, comparing rates of mental illness between EA and non-EA respondents. The findings show that EAs have similar levels of anxiety and OCD, slightly higher rates of depression, and significantly higher rates of autism compared to non-EAs. The post also discusses the relationship between consequentialism, gender, and EA, noting that EAs are much more consequentialist than non-EAs. The author concludes that while EAs may be slightly more autistic, they are not unusually self-hating or scrupulous compared to other rationalists, though both groups may differ from the general population in various ways. Shorter summary

Scott shares a diverse collection of interesting links and brief commentary on topics including linguistics, science, economics, and social issues. Longer summary

This post is a collection of interesting links and brief commentary on various topics. Scott covers subjects ranging from linguistics and philosophy to scientific discoveries and social issues. He discusses recent research on evolution, cold fusion claims, autism theories, and dark matter detection. The post also touches on economic topics like immigration effects and living costs in major cities. Scott includes some humorous content and critiques of social policies in countries like Saudi Arabia. The tone is informative and slightly humorous, with Scott offering brief personal opinions on some of the topics discussed. Shorter summary

Scott Alexander discusses the lack of scientific research on nerds, exploring potential explanations for their distinct traits, including the possible role of testosterone. Longer summary

Scott Alexander explores the lack of scientific study on nerds, despite their distinct characteristics. He lists nine common traits associated with nerds and questions why these seemingly unrelated traits often appear together. The post considers various explanations, including social factors and biological determinism, with a focus on the potential role of testosterone. Scott examines research linking low testosterone to several nerdy traits in men, but also acknowledges conflicting evidence. He concludes by noting the complexity of sex hormones and their effects, mentioning observations about transgender individuals, and questioning whether female nerds form a distinct cluster like male nerds do. Shorter summary

Scott explores how antibiotics and antiprotozoal drugs unexpectedly affect mental health, suggesting that random chemicals may frequently influence mental processes. Longer summary

Scott Alexander discusses how antibiotics and antiprotozoal drugs can have unexpected psychiatric effects, using examples like suramin for autism, minocycline for schizophrenia, iproniazid for depression, and cycloserine for anxiety disorders. He argues that this phenomenon suggests random chemicals may often affect mental processes, implying that base rates for psychiatric effects of drugs might be higher than commonly assumed. The post starts with recent research on suramin, moves through historical examples, and concludes with reflections on the implications for drug discovery and toxicity claims in psychiatry. Shorter summary

Scott Alexander examines various anti-wheat claims and pro-wheat evidence, concluding that while some concerns exist, current evidence generally supports wheat consumption for most people. Longer summary

Scott Alexander investigates the claims against wheat consumption, examining various arguments such as gluten sensitivity, intestinal permeability, wheat-derived opiates, connections to autism and schizophrenia, genetic modifications, and leptin resistance. He analyzes scientific studies and expert opinions, finding some claims to be partially true but often exaggerated or of uncertain significance. He also explores pro-wheat arguments, noting strong evidence for whole grain benefits but acknowledging potential confounders. The post concludes that while there are some concerns about wheat, the best evidence currently supports its inclusion in most people's diets. Shorter summary