Scott Alexander provides a comprehensive guide on ketamine as a depression treatment, covering administration methods, effectiveness, safety, dosage, and potential side effects. Longer summary

This post is a comprehensive guide on ketamine as a treatment for depression, covering various aspects such as methods of administration, effectiveness, safety, dosage, and potential side effects. Scott Alexander explains the differences between IV ketamine, esketamine (Spravato), and oral/intranasal ketamine, discussing their relative costs and accessibility. He also delves into ketamine-assisted psychotherapy, the duration of ketamine's effects, and current theories on how it works. The post is written in a FAQ format, aiming to provide thorough and evidence-based information while acknowledging areas of uncertainty in the research. Shorter summary

Scott Alexander maintains a list of significant mistakes in his blog posts, providing corrections and updates in reverse chronological order. Longer summary

Scott Alexander maintains a list of significant mistakes he has made in his blog posts, providing corrections and updates. He acknowledges errors in data interpretation, misunderstandings of studies, incorrect predictions, and instances where he changed his mind based on new evidence or reader feedback. The list is presented in reverse chronological order and covers a wide range of topics including medicine, economics, psychology, and social issues. Shorter summary

The post explores how emotional learning creates hard-to-update mental models, drawing parallels between psychotherapy, psychedelics, and rationality techniques in overcoming these 'mental mountains'. Longer summary

This post discusses the book 'Unlocking The Emotional Brain' (UtEB) and its implications for understanding biases and mental processes. The author explores how emotional learning creates unconscious predictive models that guide behavior, and how these models can be difficult to update even in the face of contradictory evidence. The post draws parallels between UtEB's approach, psychedelic therapy, and rationality techniques, suggesting that they all aim to overcome mental 'mountains' that separate different areas of knowledge or belief. The author proposes that these mental separations might be a necessary feature of how our brains generalize from experiences, but can also lead to problems like cognitive biases and psychiatric symptoms. The post concludes by considering how this framework might help understand and address deeply held but irrational beliefs. Shorter summary

Scott reviews a paper proposing that psychedelics work by relaxing priors in the brain, potentially treating mental illness but also risking side effects. Longer summary

This post reviews a paper by Friston and Carhart-Harris that uses predictive coding theory to explain the effects of psychedelic drugs. The authors argue that psychedelics 'relax' priors in the brain, allowing for new perspectives and potential therapeutic benefits. They suggest this mechanism could help treat most mental illnesses by allowing patients to break free from maladaptive priors. The post discusses the theory's implications, including potential downsides like HPPD and increased belief in pseudoscience. It also mentions connections to meditation and prior work by other researchers. Shorter summary

Scott explores the theory that clozapine's unique effectiveness in treating schizophrenia may be due to its combined action on dopamine and glutamate systems, potentially opening avenues for safer treatments. Longer summary

This post explores why clozapine is considered uniquely effective among antipsychotic drugs for treating schizophrenia. Scott discusses recent research suggesting clozapine's superiority may be due to its action on the glutamate system, specifically as an NMDA receptor agonist, in addition to its dopamine-blocking effects. He explains that adding NMDA modulators to other antipsychotics improves their efficacy, but not when added to clozapine, possibly because clozapine already has this effect. The post speculates that if this theory is correct, it could lead to safer treatments combining standard antipsychotics with NMDA agonists, avoiding clozapine's serious side effects. However, Scott notes that more research is needed to confirm this hypothesis and overcome regulatory hurdles. Shorter summary