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6 posts
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The Good News Is That One Side Has Definitively Won The Missing Heritability Debate

Scott examines a new genetic study on missing heritability that both hereditarians and nurturists claim vindicates their position, concluding that despite the study's advances, the fundamental debate over how heritable traits like IQ actually are remains unresolved.

acx
Dec 3, 2025 1,961 words 422 likes 589 comments Listen · 13 min Read Read

Highlights From The Comments On Missing Heritability

Scott Alexander responds to comments and criticism on his earlier post about 'Missing Heritability', discussing issues like gene-environment interactions, sequencing technology limitations, and the use of polygenic scores across ancestry groups.

acx
Jul 3, 2025 10,199 words 93 likes 131 comments Listen · 61 min Read Read

Missing Heritability: Much More Than You Wanted To Know

Scott explores the 'missing heritability' problem in genetics, where twin studies show traits like IQ and educational attainment are highly heritable but newer genomic methods find much lower heritability, analyzing various potential explanations for this discrepancy.

acx
Jun 26, 2025 10,491 words 459 likes 669 comments Listen · 62 min Read Read

It's Fair To Describe Schizophrenia As Probably Mostly Genetic

Scott Alexander argues that schizophrenia should be described as predominantly genetic, addressing counterarguments and emphasizing the importance of this perspective for prevention strategies.

acx
Feb 1, 2024 3,908 words 204 likes 303 comments Listen · 22 min Read Read

Some Unintuitive Properties Of Polygenic Disorders

Scott Alexander uses simulations to explain why seemingly counterintuitive arguments against the genetic basis of schizophrenia are misleading.

acx
Jan 24, 2024 1,561 words 229 likes 187 comments Listen · 9 min Read Read

Things I Don’t Understand About Genetics (A Non-Exhaustive List)

Scott Alexander discusses his confusion about polygenic inheritance, mutational load, and the paternal age effect in genetics, seeking explanations from readers.

ssc
Aug 23, 2013 1,097 words 0 likes 38 comments Read Read
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