Scott Alexander discusses his confusion about polygenic inheritance, mutational load, and the paternal age effect in genetics, seeking explanations from readers.
Longer summary
Scott Alexander expresses his confusion about several aspects of genetics, particularly regarding polygenic inheritance and intelligence. He starts by discussing the low contributions of individual SNPs to intelligence despite high heritability, questioning how this reconciles with the observed variation in human intelligence. He then explores the concept of mutational load and its implications, as well as the paternal age effect. Throughout the post, Scott presents various scenarios and analogies to illustrate his points of confusion, inviting readers to help explain these genetic concepts.
Shorter summary