A compilation of 55 diverse links and brief commentaries on various topics, including scientific studies, historical anecdotes, cultural phenomena, and technological developments. Longer summary

This post is a collection of 55 diverse links and brief commentaries on various topics, ranging from scientific studies and historical anecdotes to cultural phenomena and technological developments. The author covers subjects such as economic miracles, AI developments, religious trends, and social issues. Many items include claims or studies that the author finds interesting or surprising, often with a skeptical or analytical perspective. The post also includes updates on previous topics discussed by the author and references to other bloggers or researchers in the rationalist and effective altruism communities. Shorter summary

Scott Alexander examines a study challenging ketamine's effectiveness as an antidepressant, discussing potential confounding factors and maintaining his belief in ketamine's utility despite the study's results. Longer summary

Scott Alexander discusses a recent study on ketamine's effectiveness as an antidepressant when administered during anesthesia. The study found no significant difference between ketamine and placebo groups, challenging previous beliefs about ketamine's antidepressant properties. Scott analyzes the study's methodology and results, pointing out several factors that might have influenced the outcomes, such as the strong placebo effect, the antidepressant properties of anesthetics, and the potential impact of surgery on depression symptoms. He concludes that while the study raises questions, it doesn't completely invalidate previous research showing ketamine's effectiveness, and he maintains his belief in ketamine's potential as an antidepressant for some patients. Shorter summary

Scott Alexander examines the 'canalization' theory in computational psychiatry and its refinement through deep learning concepts in the Deep CANAL model. Longer summary

Scott Alexander discusses a new paradigm in computational psychiatry called 'canalization', which models mental processes as an energy landscape with valleys representing attractors or persistent beliefs/behaviors. He then explores a follow-up paper that applies concepts from deep learning to refine this theory, introducing the Deep CANAL model. This model attempts to explain various mental disorders by mapping them onto different types of computational issues in artificial neural networks, such as overfitting/underfitting and the stability/plasticity dilemma. Scott expresses both interest and skepticism about this approach, noting its potential insights but also its limitations and potential contradictions with other theories. Shorter summary

Scott Alexander addresses feedback on his post about bisexuality and Long COVID, discussing alternative explanations and defending his methodology. Longer summary

Scott Alexander responds to comments on his previous post about the correlation between bisexuality and Long COVID. He addresses alternative explanations, concerns about sample size and methodology, the nature of psychosomatic illness, and various other points raised by readers. Scott maintains that while the association exists in the data, the cause remains uncertain and could be due to various factors including response patterns, biological differences, or a combination of organic and psychosomatic elements. Shorter summary

Scott Alexander analyzes the potential role of psychopharmacology in the FTX crash, discussing medications used by SBF and others, and their possible effects on decision-making. Longer summary

Scott Alexander discusses the psychopharmacology aspects of the FTX crash, focusing on the medications Sam Bankman-Fried (SBF) and other FTX employees may have been taking. He examines claims about SBF's use of Emsam (selegiline), modafinil, and other stimulants, explaining their effects and potential risks. Scott also critiques the actions of FTX's company psychiatrist and discusses the broader implications of stimulant use in high-pressure work environments. The post ends with Scott's personal anecdote about testifying as an expert witness. Shorter summary

Scott Alexander provides a comprehensive guide on ketamine as a depression treatment, covering administration methods, effectiveness, safety, dosage, and potential side effects. Longer summary

This post is a comprehensive guide on ketamine as a treatment for depression, covering various aspects such as methods of administration, effectiveness, safety, dosage, and potential side effects. Scott Alexander explains the differences between IV ketamine, esketamine (Spravato), and oral/intranasal ketamine, discussing their relative costs and accessibility. He also delves into ketamine-assisted psychotherapy, the duration of ketamine's effects, and current theories on how it works. The post is written in a FAQ format, aiming to provide thorough and evidence-based information while acknowledging areas of uncertainty in the research. Shorter summary

Scott Alexander presents a detailed guide on depression, covering its causes, symptoms, and various treatment options, including lifestyle changes, therapies, medications, and other interventions. Longer summary

Scott Alexander provides a comprehensive guide on depression, covering its causes, symptoms, and various treatment options. He discusses lifestyle changes, therapies, medications, supplements, and other interventions like TMS and ECT. The post offers practical advice on how to approach treatment, including specific regimens for different situations, and guidelines on how long to continue treatment once it starts working. Shorter summary

Scott Alexander investigates the optimal dosage of Lexapro, comparing it to other antidepressants and exploring the reasons behind its effectiveness at lower doses. Longer summary

Scott Alexander explores the question of the right dose for Lexapro (escitalopram), an antidepressant. He examines official recommendations, compares Lexapro to other SSRIs, and investigates why Lexapro might be effective at lower doses. The post delves into studies on antidepressant dosing, the unique properties of Lexapro, and the potential benefits and risks of higher doses. Scott concludes that while there's no strong evidence for high doses of any antidepressant being more effective, prescribing higher doses of Lexapro might be as safe as other SSRIs and potentially more beneficial in some cases. Shorter summary

Scott Alexander discusses new research suggesting ketamine's antidepressant effects may be linked to the opioid system, exploring the implications and potential future directions for depression treatment. Longer summary

Scott Alexander provides an update on ketamine research, discussing a new study that suggests ketamine's antidepressant effects may be related to the opioid system rather than NMDA receptors as previously thought. He compares this to a study on buprenorphine's effects on suicidal ideation and explores the implications of these findings. The post touches on the medical establishment's response, potential future directions for research and treatment, and the historical context of opiate use in medicine. Scott also raises questions about the relationship between opiates and depression, and the potential risks and benefits of using opioid-related treatments for depression. Shorter summary

Scott Alexander examines whether psychiatrists should test for lead more often, concluding that while it could be relevant in some cases, there's not enough evidence to justify universal testing. Longer summary

Scott Alexander discusses the question of whether psychiatrists should test for lead more often in patients with mental health issues. He presents a case where lead poisoning was found to be a factor in a patient's psychiatric symptoms, and explores the broader implications of this. Scott then examines the complexities of deciding which potential factors to test for in psychiatric practice, given the numerous possible causes of depression and other mental health issues. He argues that while lead could be a factor in some cases, there's insufficient evidence to justify universal testing. He also discusses the challenges of interpreting and acting on test results, especially when they fall within normal ranges. Scott concludes by reflecting on different approaches to medical practice and the difficulties of balancing evidence-based guidelines with emerging theories and individual clinical judgment. Shorter summary

Scott Alexander examines the risks of Adderall use, analyzing medical, addiction, tolerance, and neurotoxicity concerns, concluding that the benefits outweigh the risks for well-informed patients. Longer summary

Scott Alexander explores the risks of Adderall use, examining medical risks, addiction potential, tolerance development, and possible neurotoxicity. He critically analyzes existing research and shares his clinical experience, ultimately concluding that while there are some concerning risks, they are not severe enough to stop prescribing stimulants to patients who might benefit from them, provided they are well-informed about the risks. Shorter summary

The post explores the complex relationship between smoking and schizophrenia, critiquing conflicting studies and cautioning against hasty conclusions about nicotine's effects on schizophrenia risk. Longer summary

This post examines the relationship between smoking and schizophrenia. It starts by noting the high prevalence of smoking among schizophrenics and discusses various theories for this, including the self-medication hypothesis. The author then analyzes two conflicting studies on whether smoking causes or prevents schizophrenia. One study suggests smoking increases risk, while another, which controls for confounders, indicates smoking may decrease risk. The post criticizes how the first study, despite being newer, ignores the contradictory findings of the second study. The author expresses frustration with this scientific approach and cautions against pushing people at risk of schizophrenia away from nicotine without stronger evidence. The post ends by noting that smoking definitely decreases Parkinson's Disease risk and reiterating that tobacco smoking is still harmful overall. Shorter summary

Scott analyzes various criticisms of antidepressants, concluding they have modest but real benefits over placebo, with important considerations about side effects and efficacy. Longer summary

This post examines various criticisms of SSRIs and antidepressants, addressing claims about their efficacy, side effects, and comparisons to placebo and psychotherapy. Scott analyzes studies on antidepressant effectiveness, discussing issues like publication bias, effect sizes, and the meaning of 'clinical significance'. He explores side effects, particularly sexual dysfunction, weight gain, and emotional blunting. The post concludes that while antidepressants are not miracle drugs, they do have a modest but statistically significant benefit over placebo and can be a reasonable option for many people with depression, especially if they understand and prepare for potential side effects. Shorter summary

Scott criticizes a study linking childhood bullying to negative adult outcomes, arguing that its method of controlling for confounders is inadequate and proposing alternative explanations for the correlation. Longer summary

Scott criticizes a study claiming that childhood bullying victimization leads to negative adult outcomes. He argues that the study's attempt to control for confounding factors is inadequate, as bullies are likely better at identifying vulnerable children than the researchers' measures. Scott suggests that unmeasured factors like height could explain the correlation, and that the study's method of adjusting for confounders is unreliable. He proposes that a proper study would involve an anti-bullying intervention with control schools. The post also mentions a contrasting study that found no association after adjusting for confounders, and questions the reliability of parent reports on bullying used in the original study. Shorter summary

Scott Alexander presents a diverse collection of recent news items, studies, and interesting facts, covering topics from public health to economics to quirky trivia. Longer summary

This post is a collection of diverse news items, studies, and interesting facts curated by Scott Alexander. It covers a wide range of topics including public health policies, economics, scientific discoveries, social issues, and quirky facts. Scott provides brief commentary on many of the items, often with a touch of humor or irony. The post doesn't have a central theme but rather serves as a roundup of interesting information Scott has come across recently. Shorter summary

Scott Alexander examines a study showing no significant difference between CBT and psychodynamic therapy, challenging the idea that CBT is superior and exploring the possibility that most psychotherapies work through non-specific factors. Longer summary

Scott Alexander discusses a recent study in the American Journal of Psychiatry comparing the efficacy of cognitive-behavioral therapy (CBT) and psychodynamic therapy for depression. The study found no significant difference between the two therapies, challenging the common belief that CBT is superior. Scott reflects on how this contradicts the 'foundation myth' of psychiatry, which claims that evidence-based therapies like CBT replaced less scientific approaches like Freudian psychoanalysis. He explores the possibility that most psychotherapies work through non-specific factors rather than their specific theories or techniques, a concept known as the Dodo Bird Verdict. Scott suggests that CBT's reputation as evidence-based may be due to its proponents conducting more studies, rather than superior efficacy. He concludes by stating his belief that only very basic, targeted therapies have specific effects, while more complex theories of the mind likely rely on non-specific factors. Shorter summary