A compilation of 55 diverse links and brief commentaries on various topics, including scientific studies, historical anecdotes, cultural phenomena, and technological developments.

Scott Alexander examines a study challenging ketamine's effectiveness as an antidepressant, discussing potential confounding factors and maintaining his belief in ketamine's utility despite the study's results.

Scott Alexander examines the 'canalization' theory in computational psychiatry and its refinement through deep learning concepts in the Deep CANAL model.

Scott Alexander addresses feedback on his post about bisexuality and Long COVID, discussing alternative explanations and defending his methodology.

Scott Alexander analyzes the potential role of psychopharmacology in the FTX crash, discussing medications used by SBF and others, and their possible effects on decision-making.

Scott Alexander provides a comprehensive guide on ketamine as a depression treatment, covering administration methods, effectiveness, safety, dosage, and potential side effects.

Scott Alexander presents a detailed guide on depression, covering its causes, symptoms, and various treatment options, including lifestyle changes, therapies, medications, and other interventions.

Scott Alexander investigates the optimal dosage of Lexapro, comparing it to other antidepressants and exploring the reasons behind its effectiveness at lower doses.

Scott Alexander discusses new research suggesting ketamine's antidepressant effects may be linked to the opioid system, exploring the implications and potential future directions for depression treatment.

Scott Alexander examines whether psychiatrists should test for lead more often, concluding that while it could be relevant in some cases, there's not enough evidence to justify universal testing.

Scott Alexander examines the risks of Adderall use, analyzing medical, addiction, tolerance, and neurotoxicity concerns, concluding that the benefits outweigh the risks for well-informed patients.

The post explores the complex relationship between smoking and schizophrenia, critiquing conflicting studies and cautioning against hasty conclusions about nicotine's effects on schizophrenia risk.

Scott analyzes various criticisms of antidepressants, concluding they have modest but real benefits over placebo, with important considerations about side effects and efficacy.

Scott criticizes a study linking childhood bullying to negative adult outcomes, arguing that its method of controlling for confounders is inadequate and proposing alternative explanations for the correlation.

Scott Alexander presents a diverse collection of recent news items, studies, and interesting facts, covering topics from public health to economics to quirky trivia.

Scott Alexander examines a study showing no significant difference between CBT and psychodynamic therapy, challenging the idea that CBT is superior and exploring the possibility that most psychotherapies work through non-specific factors.