Scott explores GABA-A receptor subunits, their effects, and how various drugs interact with them, discussing potential for more selective drug development. Longer summary

This post explores GABA-A receptor subunits and their role in psychiatric drugs and supplements. It explains the structure of GABA-A receptors, focusing on the alpha subunits and their associated effects. The post discusses how different drugs like benzodiazepines and zolpidem (Ambien) interact with these subunits, and mentions attempts to create more selective drugs. It also touches on the role of GABA receptors in alcohol's effects and the classification of Z-drugs. The author includes personal experiences with supplements claiming to have selective GABA modulation. Shorter summary

Scott responds to various comments on his article about supplement labeling, addressing concerns about the industry and providing additional context and analysis. Longer summary

This post is a highlights reel of comments on Scott's previous article about supplement labeling. It covers various points raised by commenters, including skepticism about the supplement industry, concerns about heavy metal contamination, and a defense from the founder of LabDoor. Scott responds to each comment, providing additional context, analysis, and sometimes his own perspective on the issues raised. The post touches on topics such as the efficacy of supplements, the trustworthiness of supplement testing companies, and the potential risks associated with certain types of supplements. Shorter summary

Scott Alexander examines skeptical and supportive comments on claims of enlightenment, arguing that evidence for such states is comparable to other accepted mental phenomena. Longer summary

This post discusses the comments on a previous article about Persistent Non-Symbolic Experience (PNSE) or 'enlightenment'. Scott Alexander addresses skepticism towards claims of enlightenment, comparing it to other mental states and discussing the evidence for its existence. He argues that the evidence for enlightenment-like states is as strong as for many other accepted mental phenomena. The post also explores different perspectives on enlightenment, including potential criticisms and alternative explanations, as well as personal accounts from individuals with meditation experience. Shorter summary

Scott Alexander hypothesizes a link between transgender identity, optical illusions, and NMDA receptor function, based on survey data and existing research on schizophrenia and autism. Longer summary

Scott Alexander explores a potential link between transgender identity, optical illusions, and NMDA receptor function in the brain. He presents survey data suggesting that transgender individuals, like those with schizophrenia and autism, are less susceptible to certain optical illusions. He hypothesizes that this might be related to NMDA receptor hypofunction, which is also associated with dissociation, a common experience among transgender people. The post explores how estrogen, which enhances NMDA function, alleviates dissociation in trans women. Scott connects these findings to broader research on NMDA receptors in schizophrenia and autism, noting the higher prevalence of these conditions in transgender populations. The post concludes with several caveats and suggestions for future research to validate these speculative connections. Shorter summary

Scott Alexander examines a theory linking autism and schizophrenia to human self-domestication, initially dismissing it before reconsidering its merits in light of Williams Syndrome. Longer summary

Scott Alexander discusses a theory suggesting that autism and schizophrenia are anomalies in human self-domestication. He initially dismisses the theory, pointing out inconsistencies and over-reaching comparisons. However, he then considers Williams Syndrome, which appears to fit the 'hyperdomestication' model better. Scott concludes that while autism and schizophrenia may not be exact opposites of domestication, they likely involve a biological system determining trust and sociability, which is linked to embryological development. He suggests that an embryological approach might be more fruitful in studying these conditions. Shorter summary

A collection of interesting links spanning scientific research, politics, economics, and culture, with brief commentary from Scott Alexander on each item. Longer summary

This is a links post, where Scott Alexander shares and briefly comments on various interesting articles, studies, and news items. The post covers a wide range of topics including scientific studies about genetics, intelligence, and obesity; political news about Donald Trump and Bernie Sanders; economic research about minimum wage and business practices; and various other topics like climate change and mathematical curiosities. Scott provides short commentary and often connects the links to previous discussions or adds context from his own knowledge. Shorter summary

Scott Alexander shares insights and critiques from a psychiatry conference, covering topics from medication prescribing rights to new monitoring technologies and research methodologies. Longer summary

Scott Alexander humorously recounts his experience at a psychiatry conference, highlighting various issues in the field. He discusses the debate over psychologists prescribing medication, new technologies for monitoring schizophrenic patients, problems with certain study designs, the effectiveness of long-acting injectable antipsychotics, and the superiority of clozapine. He also touches on political lobbying in psychiatry and the influence of drug companies. The post is written with a mix of seriousness and sardonic humor, critiquing various aspects of psychiatric practice and research. Shorter summary