A compilation of 55 diverse links and brief commentaries on various topics, including scientific studies, historical anecdotes, cultural phenomena, and technological developments.

Scott Alexander recounts his experience donating a kidney, from initial motivation to post-surgery recovery, while discussing the broader context of organ donation.

Scott Alexander critiques Ben Hoffman's arguments about Vitamin D dosing, maintaining that it is primarily a bone-related chemical with limited evidence for other benefits.

Scott Alexander examines obscure pregnancy interventions that may improve child outcomes, rating them by evidence quality and potential impact.

Scott Alexander examines melatonin's effects, proper dosage, and uses for sleep disorders and circadian rhythm issues, emphasizing its dual role as a hypnotic and chronobiotic.

Scott Alexander offers Christmas shopping recommendations for various products, from balsamic vinegar to nootropics, with personal insights on each item.

Scott Alexander reviews a wide range of treatments for anxiety disorders, from lifestyle changes and therapy to medications and alternative remedies, emphasizing the importance of exploring multiple options.

Scott Alexander offers a comprehensive guide for treating depression, covering professional help, lifestyle changes, and supplements, emphasizing the importance of persistence in finding effective treatments.