A review of 'Great and Desperate Cures' by Elliot Valenstein, which examines the history of lobotomy and psychosurgery, explaining how tens of thousands of patients underwent dangerous brain operations from the 1930s-1950s despite poor evidence of effectiveness.

Scott responds to three concerns about embryo selection: embryo personhood rights, loss of trait diversity, and the ethics of preventing disabilities, arguing that none of these objections are fatal to the technology.

Scott announces a new subscriber-only AMA session, setting clear boundaries about which questions he will and won't answer.

A review of 'Two Arms and a Head', a paraplegic's memoir and argument for physician-assisted suicide, exploring the book's content and the broader debate around Medical Assistance in Dying.

Scott Alexander examines the problematic nature of emotional support animal letters, highlighting the ethical dilemmas for psychiatrists and the system's shortcomings.

Scott Alexander argues that using polygenic screening to select low-risk embryos can be considered as preventing genetic disorders, drawing parallels with other accepted preventive practices.

Scott Alexander argues that schizophrenia should be described as predominantly genetic, addressing counterarguments and emphasizing the importance of this perspective for prevention strategies.

Scott Alexander summarizes and responds to various comments on his kidney donation post, covering a wide range of related topics and perspectives.

Scott Alexander recounts his experience donating a kidney, from initial motivation to post-surgery recovery, while discussing the broader context of organ donation.

Scott Alexander critiques the Social Model of Disability as flawed and proposes the Biopsychosocial Model as a more balanced alternative.

Scott Alexander summarizes and responds to comments on his book review about IRBs, covering various perspectives on research regulation.

Scott Alexander responds to comments on his post about new telemedicine regulations, addressing various concerns and criticisms raised by readers.

Scott Alexander analyzes the potential role of psychopharmacology in the FTX crash, discussing medications used by SBF and others, and their possible effects on decision-making.

Scott Alexander argues that doctors should prescribe fluvoxamine for COVID-19 despite FDA inaction, urging them to overcome discomfort with off-label use when evidence supports it.

Scott Alexander examines the concept of 'Pascalian Medicine', weighing the pros and cons of taking multiple unproven but potentially beneficial treatments.

Scott summarizes and responds to comments on his previous article about FDA approval of Paxlovid, acknowledging some valid points while maintaining his criticism of the approval process.

Scott Alexander corrects and expands on the story of Omegaven, a life-saving infant nutritional fluid, using it to illustrate systemic issues with medical regulation and drug approval.

Scott Alexander argues that the FDA is too strict, not too lax, and proposes unbundling FDA approval to allow for more nuanced drug regulation.

The post examines the medical benefits, risks, and ethical considerations of infant circumcision, presenting a balanced view based on various studies and historical context.

Scott Alexander discusses the ethical dilemma of writing doctor's notes for back pain as a psychiatrist, leading to reflections on 'bullshit jobs' and procedural inefficiencies in the economy.

Scott Alexander offers a detailed guide on navigating the inpatient mental health system, balancing caution with the importance of seeking necessary treatment.

Scott shares reader responses to his IRB experience, ranging from similar frustrations to defenses of the system, and discusses concerns about increasing bureaucracy in research.

Scott Alexander explores the complex ethical and legal issues surrounding sexual consent for institutionalized and intellectually disabled individuals, arguing for a nuanced approach that balances protection and autonomy.

Scott Alexander reviews 'House of God', a satirical novel about medical internship that exposed systemic issues in healthcare and influenced real-world changes.

Scott Alexander shares his experiences and reflections as a final-year psychiatric resident, discussing communication techniques, challenges in psychotherapy, and the anxiety of managing patient risks.