A review of the synaptic plasticity and memory hypothesis arguing that it is insufficient to explain memory, and proposing a broader cellular processes and memory hypothesis that includes molecular and intracellular mechanisms. Longer summary

The post reviews the synaptic plasticity and memory (SPM) hypothesis, which claims that learning and memory are stored in changes to synaptic weights between neurons. Through several compelling examples, from cannibalism rituals to heart transplant stories and single-cell learning, the author argues that while the SPM hypothesis has been productive, it is incomplete and partially wrong. The post presents evidence that memory can be stored through non-synaptic mechanisms, and proposes an alternative called the cellular processes and memory (CPM) hypothesis, which suggests memory storage involves multiple molecular and intracellular processes beyond just synaptic weights. Shorter summary

Scott explores the 'missing heritability' problem in genetics, where twin studies show traits like IQ and educational attainment are highly heritable but newer genomic methods find much lower heritability, analyzing various potential explanations for this discrepancy. Longer summary

The post examines the 'missing heritability' problem in genetics, where twin studies consistently show behavioral traits like IQ and educational attainment are substantially heritable (around 40-60%), while newer genomic methods find much lower heritability (around 15-20%). Scott reviews the history of behavioral genetics research, explains various study methodologies and their potential biases, and analyzes different hypotheses for this discrepancy. He examines whether twin studies might be flawed, whether newer methods might be missing important genetic effects, and whether educational attainment might be an unusually problematic trait to study. While acknowledging remaining mysteries, he tentatively concludes that twin studies are probably largely correct and that newer methods may be missing rare variants and genetic interactions. Shorter summary

Scott Alexander proposes a theory of depression as a recalibrated happiness set point, drawing parallels with fever and anorexia, to explain why depressed people seek out sad stimuli. Longer summary

Scott Alexander explores the puzzling behavior of depressed people preferring sad music, despite it making them feel worse. He proposes a theory based on control theory and set points, comparing depression to conditions like fever and anorexia. The post suggests that depression might involve a recalibrated happiness set point, where the body defends an abnormally low mood through both biological and behavioral mechanisms. Scott also discusses potential research directions and connects this theory to predictive coding concepts. Shorter summary

Scott Alexander presents a diverse collection of 38 links and news items, covering topics from book reviews and religious history to AI developments and political trends, with brief summaries and comments on each. Longer summary

This post is a collection of 38 diverse links and news items covering topics such as book reviews, religious history, economic forecasts, libertarianism, crime statistics, scientific studies, AI developments, educational policies, and political trends. Scott Alexander provides brief summaries or comments on each item, often with a mix of factual information and his own perspective. The links range from academic studies to social media posts, covering current events, historical anecdotes, and ongoing debates in various fields. Shorter summary

Scott Alexander critiques the Social Model of Disability as flawed and proposes the Biopsychosocial Model as a more balanced alternative. Longer summary

Scott Alexander critiques the Social Model of Disability, which claims that disability is solely caused by societal barriers and not by individual impairments. He argues that this model, while well-intentioned, is flawed and often taken too literally. Scott proposes the Biopsychosocial Model as a more balanced alternative, acknowledging both biological and social factors in disability. He discusses the history of the Social Model, its limitations, and why a more nuanced approach is necessary for understanding and addressing disabilities. Shorter summary

Scott Alexander addresses feedback on his post about bisexuality and Long COVID, discussing alternative explanations and defending his methodology. Longer summary

Scott Alexander responds to comments on his previous post about the correlation between bisexuality and Long COVID. He addresses alternative explanations, concerns about sample size and methodology, the nature of psychosomatic illness, and various other points raised by readers. Scott maintains that while the association exists in the data, the cause remains uncertain and could be due to various factors including response patterns, biological differences, or a combination of organic and psychosomatic elements. Shorter summary

Scott Alexander argues that a purely biological, apolitical taxonomy of mental disorders is impossible due to ethical and practical considerations that inevitably influence classifications. Longer summary

Scott Alexander discusses the limitations of creating a purely biological, apolitical taxonomy of mental disorders. He argues that such a taxonomy is inherently impossible because the classification of mental disorders is not just a scientific issue, but also a practical and ethical one. Using examples like transgender identity, homosexuality, and pedophilia, he demonstrates how biological similarities can conflict with ethical and practical considerations in classification. The post highlights the tension between scientific accuracy, stigma avoidance, and ensuring access to necessary care. Scott concludes that new taxonomies like HiTOP are still useful, but claims of avoiding political bias in disorder classification are unrealistic. Shorter summary

Anna Schaffner's 'Exhaustion: A History' traces explanations for chronic fatigue from ancient times to modern Chronic Fatigue Syndrome, showing how they reflect contemporary cultural and scientific ideas. Longer summary

The book 'Exhaustion: A History' by Anna Schaffner explores the concept of chronic, pathological exhaustion throughout Western history. It traces various explanatory models used in science and culture, from ancient humoral theory to modern conceptions of Chronic Fatigue Syndrome (CFS). The author argues that while the symptoms have remained consistent, the explanations for exhaustion have changed over time, reflecting contemporary cultural and scientific ideas. The book covers religious, moral, sexual, and medical explanations, culminating in the current debates surrounding CFS and its controversial status in modern medicine. Shorter summary

A review of 'Viral' by Chan and Ridley explores competing hypotheses about COVID-19's origins, critiquing institutional responses and emphasizing ongoing uncertainty. Longer summary

This book review discusses 'Viral' by Alina Chan and Matt Ridley, which explores the origins of the COVID-19 pandemic. The reviewer summarizes key points from the book, including evidence for both natural and lab leak hypotheses, the history of lab leaks, the relevance of Wuhan's location, and criticisms of institutional responses. The review also covers technical evidence and debates around it, while emphasizing the reviewer's uncertainty about the pandemic's true origin. The author concludes by reflecting on the role of amateur researchers and the importance of scientific self-correction. Shorter summary

A review of Stanislas Dehaene's 'Consciousness and the Brain', discussing scientific findings on consciousness and their implications. Longer summary

This review discusses Stanislas Dehaene's book 'Consciousness and the Brain', which explores the scientific understanding of consciousness. The book defines consciousness as the ability to report on a perception, and describes experiments that differentiate conscious from unconscious processing. It explains what the brain can do unconsciously, what requires consciousness, and how consciousness operates in the brain. The review also covers the book's insights on topics like schizophrenia and the 'hard problem' of consciousness. Shorter summary

Scott Alexander examines obscure pregnancy interventions that may improve child outcomes, rating them by evidence quality and potential impact. Longer summary

Scott Alexander reviews various obscure pregnancy interventions that could potentially improve child outcomes, particularly IQ. He rates them in tiers based on evidence strength and potential impact, with Tier 1 being most strongly supported. Key interventions discussed include embryo selection, choline supplementation, avoiding stress and certain substances, and optimizing birth timing. He emphasizes these are extreme measures not meant to induce guilt, and that standard pregnancy advice is still most important. Shorter summary

Scott Alexander examines why certain families produce multiple generations of high achievers, exploring genetic, environmental, and psychological factors. Longer summary

Scott Alexander explores the phenomenon of highly accomplished families, such as the Huxleys, Darwins, and Curies, who have produced multiple generations of notable scientists, artists, and leaders. He discusses potential explanations for this trend, including privilege, genetics, and unique family environments. The post delves into the role of assortative mating, large family sizes, and the correlation between different types of talents. It also touches on the concept of a 'Hero License' - the idea that coming from an accomplished family might instill the confidence to pursue ambitious goals. Shorter summary

Scott Alexander presents a monthly collection of 42 diverse links covering topics from science, politics, culture, and technology, highlighting interesting findings and current events. Longer summary

This post is a collection of 42 diverse links and topics, ranging from scientific studies to political news and cultural observations. Scott Alexander curates these links monthly, covering a wide array of subjects including zoology, sociology, economics, psychology, technology, and more. The links often highlight interesting or surprising findings, such as studies on cult demographics, obesity research controversies, and the effects of testosterone on belief in minority positions. Scott also includes humorous content, political commentary, and discussions on current events and social trends. Shorter summary

A critical review of Rutger Bregman's 'Humankind', analyzing its argument that human nature is fundamentally good, while highlighting both flaws and valuable insights in the book. Longer summary

This review critiques Rutger Bregman's book 'Humankind', which argues that human nature is fundamentally good. The reviewer analyzes Bregman's arguments, pointing out logical inconsistencies and cherry-picked data, while also acknowledging some valuable insights. The book covers topics such as human behavior during crises, the nature of empathy and power, and alternative approaches to management and democracy. The review concludes that while Bregman's thesis has flaws, his core message about trusting and respecting others more has merit. Shorter summary

Scott Alexander presents a detailed guide on depression, covering its causes, symptoms, and various treatment options, including lifestyle changes, therapies, medications, and other interventions. Longer summary

Scott Alexander provides a comprehensive guide on depression, covering its causes, symptoms, and various treatment options. He discusses lifestyle changes, therapies, medications, supplements, and other interventions like TMS and ECT. The post offers practical advice on how to approach treatment, including specific regimens for different situations, and guidelines on how long to continue treatment once it starts working. Shorter summary

Scott Alexander shares a diverse collection of links on topics ranging from scientific studies to historical anecdotes, with brief commentary on each. Longer summary

This post is a collection of various links and brief summaries on diverse topics. It covers scientific studies, historical anecdotes, political developments, and cultural phenomena. The topics range from new malaria control methods and gender transition studies to the economics of dictatorships and the history of rat-baiting. Scott Alexander provides commentary on some of the links, often with a touch of humor or irony. The post also includes updates on ongoing debates in fields like psychology, nutrition, and climate change. Shorter summary

Scott Alexander uses the evolution of genetic science as a metaphor to explore how other fields might benefit from recognizing the polycausal nature of complex phenomena. Longer summary

Scott Alexander discusses the evolution of genetic science, from the search for single genes responsible for complex traits to the current understanding that almost all genes contribute to these traits. He uses this as a metaphor for other sciences, particularly psychiatry, suggesting that many fields may be more polycausal than initially thought. The post explores the implications of this shift, including skepticism about personalized medicine and the potential need for new approaches to scientific research that can handle massive numbers of interacting causes. Scott concludes by imagining a hypothetical alien society where science is centered around polycausal scores, presenting this as a thought experiment for what science could aspire to be. Shorter summary

Scott Alexander presents a diverse collection of links and brief commentary on topics ranging from historical anecdotes to recent scientific studies and political developments. Longer summary

This post is a collection of various links and brief commentary on diverse topics. It covers historical anecdotes, scientific studies, political developments, and cultural phenomena. The post touches on subjects like vegetarian activism, Supreme Court changes, AI alignment, and Silicon Valley culture. Scott Alexander provides concise summaries and occasional personal opinions on these wide-ranging topics, often with a touch of humor or irony. Shorter summary

The post reviews research on adult neurogenesis, initially presenting evidence for its existence and importance, then reveals a new study suggesting it doesn't occur in humans, examining the implications of this potential field-wide error. Longer summary

This post reviews the literature on adult neurogenesis, initially presenting numerous studies that claimed to find evidence for the generation of new neurons in adult human brains. These studies linked adult neurogenesis to various aspects of brain function, including memory, learning, and depression. However, the post then reveals a new study suggesting that adult neurogenesis doesn't actually occur in humans, or is so rare as to be insignificant. The author examines how this field-wide error could have occurred, discussing the extrapolation of rat studies to humans and the role of confirmation bias. The post ends by reflecting on the implications of this for scientific research and the replication crisis. Shorter summary

Scott Alexander presents a wide-ranging collection of links covering science, technology, politics, economics, and culture, with brief commentary on each item. Longer summary

Scott Alexander shares a collection of interesting links and news items on various topics. He discusses punding (a side effect of dopamine drugs), net neutrality in Montana, Tibetan monks' fear of death, Trump's solar panel tariffs, space exploration news, a potential tinnitus treatment, the US metric system history, NSA's core values change, a Burning Man activist's story, blockchain projects, Aristotle's puns, UK politician Jacob Rees-Mogg, arguments against open borders, new education programs, SAT score correlations, solar system geography, Amazon's entry into healthcare, pain tolerance and friendships, legal terminology origins, campus free speech issues, Twitter bots, nutrition studies, IQ test incentives, dating apps for verified Twitter users, Hitler's drug use, mindfulness research, disability insurance effects, asteroid naming conventions, and various other topics. Shorter summary

A collection of interesting links covering topics from ancient Roman demographics to modern AI developments, criminal justice issues, and cultural oddities. Longer summary

This is a links post collecting various interesting news and articles. Topics include ancient Roman life expectancy data, Chinese censorship expanding to group chats, cruise ship pollution, AI developments like AlphaGo Zero, criminal justice issues around drug rehab work camps and police body cameras, and various other scientific, technological and cultural items. The post maintains a light tone while covering both serious topics like Puerto Rico's ongoing crisis and quirky ones like Viking reenactors and Halloween costumes. Shorter summary

Scott Alexander distinguishes between 'universal culture' and 'Western culture', exploring how the former outcompetes all traditional cultures and the ethical implications of this process. Longer summary

Scott Alexander discusses the concept of 'universal culture' as distinct from 'Western culture', arguing that what is often called 'Westernization' is actually the spread of a culture optimized for industrial societies. He explains how this universal culture outcompetes traditional cultures, including Western culture itself, and explores the ethical implications of this process. The post concludes by considering whether we should support or resist the spread of universal culture, acknowledging the complexity of the issue without reaching a definitive stance. Shorter summary

Scott reviews 'Unlearn Your Pain', finding its psychosomatic theory of chronic pain intriguing but overstated, while acknowledging the book's techniques may still be helpful via placebo effects. Longer summary

Scott reviews the book 'Unlearn Your Pain' by Dr. Howard Schubiner, which argues that most chronic pain is psychosomatic and can be cured through psychological techniques. While Scott finds some of the book's claims intriguing, he is skeptical of its more sweeping assertions about the psychological origins of pain. He examines the evidence for and against psychosomatic theories of chronic pain, concluding that while psychological factors likely play a role, the book overstates its case and ignores contradictory evidence. Scott suggests the book's techniques may work primarily through placebo effects rather than by addressing repressed trauma as claimed. Shorter summary

Scott shares various interesting links and findings, including studies on education and IQ, brain simulation challenges, obesity surgery outcomes, and various cultural curiosities. Longer summary

This is a links post where Scott Alexander shares various interesting findings, research, and curiosities. He discusses several scientific studies, including research on education's effect on IQ from Sweden, brain simulation challenges, and obesity surgery outcomes. The post also includes various cultural and historical curiosities, like England's high tornado rate, Lenin being called a mushroom, and the Great Pyramid's eight sides. Scott provides commentary and analysis on many of the links, particularly regarding scientific research and methodology. The format is casual but informative, with Scott adding personal insights and occasional humor throughout. Shorter summary

A links roundup post covering recent developments in science, medicine, psychology and politics, with particular focus on research replication issues and the 2016 election season. Longer summary

This is a links roundup post covering various recent research findings, news, and developments. It covers topics from toxoplasma research, drug trials, and scientific replication crises to politics and social issues. The post discusses several important developments in psychology including failed replications of established theories like ego depletion, updates on clinical trials and drug research, and various political developments around the 2016 election season. It maintains a light tone while discussing serious academic and scientific topics, including several meta-analyses and study critiques. Shorter summary