Josh Morrison argues that AI superforecasting could transform FDA drug approval by replacing subjective expert judgment with objective, quantitative predictions about drug safety and efficacy.

Scott examines the concept of 'priesthoods' (like medicine and academia) as epistemic communities that maintain high standards through isolation from the public, showing both their strengths and their vulnerability to ideological capture.

Scott Alexander examines how compounding pharmacies are producing cheaper versions of GLP-1 agonist drugs, exploring the economics, safety, and future implications of this practice.

Scott Alexander presents a diverse collection of 49 links and brief commentaries on various topics, ranging from cultured meat to AI developments and current events.

Scott examines data on COVID-19 lockdown effectiveness, finding they likely reduced transmission but at significant costs, with targeted measures being most effective.

Scott Alexander investigates the optimal dosage of Lexapro, comparing it to other antidepressants and exploring the reasons behind its effectiveness at lower doses.

Scott Alexander discusses various aspects of the COVID-19 pandemic, including strategies, mysteries, controversies, and global impacts.

Scott shares and comments on a diverse collection of news items and interesting links from March 2014, covering topics from medical advances to political issues and quirky stories.