Scott Alexander recounts his experience donating a kidney, from initial motivation to post-surgery recovery, while discussing the broader context of organ donation. Longer summary

Scott Alexander describes his journey to donate a kidney, including his motivations, the medical process, and the challenges he faced. He discusses the effectiveness of kidney donation compared to other forms of altruism, the stigma around mental health in the donation process, and the need for systemic changes to address the kidney shortage. Scott also reflects on the experience of the surgery and recovery, and encourages others to consider donation. Shorter summary

Scott Alexander investigates the reliability of dietary supplements, finding that while issues exist, most are not completely fake as some media reports claim. Longer summary

Scott Alexander examines the trustworthiness of dietary supplements, debunking widespread claims that most are completely fake. He analyzes studies, consumer lab reports, and industry insider accounts to conclude that while there are issues in the supplement industry, outright fraud is rare, especially for common vitamins and minerals. More complex botanicals and trendy supplements may have more variability, but complete absence of active ingredients is uncommon. Scott suggests consumers should be discerning, especially with lesser-known products, but notes that for many supplements, precise dosing may not be critical. Shorter summary

Anna Schaffner's 'Exhaustion: A History' traces explanations for chronic fatigue from ancient times to modern Chronic Fatigue Syndrome, showing how they reflect contemporary cultural and scientific ideas. Longer summary

The book 'Exhaustion: A History' by Anna Schaffner explores the concept of chronic, pathological exhaustion throughout Western history. It traces various explanatory models used in science and culture, from ancient humoral theory to modern conceptions of Chronic Fatigue Syndrome (CFS). The author argues that while the symptoms have remained consistent, the explanations for exhaustion have changed over time, reflecting contemporary cultural and scientific ideas. The book covers religious, moral, sexual, and medical explanations, culminating in the current debates surrounding CFS and its controversial status in modern medicine. Shorter summary

A detailed review of Michael Shellenberger's 'San Fransicko', examining its critiques of San Francisco's progressive policies on homelessness, drugs, and crime. Longer summary

This post reviews Michael Shellenberger's book 'San Fransicko', which criticizes progressive policies on homelessness, drug addiction, and crime in San Francisco. The review examines key claims in the book, fact-checking statistics and comparing them to other sources. While finding some of Shellenberger's criticisms valid, the review also points out areas where the book presents a one-sided narrative or misrepresents data. Overall, the reviewer sees the book as a flawed but thought-provoking critique of San Francisco's approach to urban problems. Shorter summary

Scott Alexander examines obscure pregnancy interventions that may improve child outcomes, rating them by evidence quality and potential impact. Longer summary

Scott Alexander reviews various obscure pregnancy interventions that could potentially improve child outcomes, particularly IQ. He rates them in tiers based on evidence strength and potential impact, with Tier 1 being most strongly supported. Key interventions discussed include embryo selection, choline supplementation, avoiding stress and certain substances, and optimizing birth timing. He emphasizes these are extreme measures not meant to induce guilt, and that standard pregnancy advice is still most important. Shorter summary

Scott Alexander reviews David Sinclair's optimistic book on anti-aging research, discussing its main claims and potential criticisms. Longer summary

Scott Alexander reviews David Sinclair's book 'Lifespan', which argues that aging is primarily caused by epigenetic damage and can be easily solved. Sinclair proposes activating sirtuin proteins through various means like calorie restriction, exercise, or supplements to repair this damage. The review covers Sinclair's main arguments, potential criticisms, and broader philosophical questions about extending human lifespan. Scott expresses some skepticism about Sinclair's optimism but acknowledges the potential benefits of anti-aging research. Shorter summary

Scott Alexander analyzes ivermectin studies for COVID-19, finding most positive results likely due to methodological flaws, fraud, or confounding by parasitic infections. Longer summary

Scott Alexander provides an in-depth analysis of ivermectin studies for COVID-19 treatment, examining methodological issues, potential fraud, and confounding factors. He concludes that ivermectin likely doesn't significantly reduce COVID mortality except potentially in areas with high parasitic worm infections. The post explores broader issues around scientific credibility, fraud detection, and public trust in science. Shorter summary

Scott Alexander presents a curated list of 37 diverse and interesting links, covering topics from historical events to recent scientific studies, with brief summaries and occasional commentary. Longer summary

This post is a collection of 37 links to various articles, studies, and interesting facts across a wide range of topics. Scott Alexander presents these links with brief summaries or comments, covering subjects from historical events and scientific studies to economic theories and technological advancements. The tone is informative and sometimes humorous, with Scott occasionally offering personal opinions or admitting to previous errors. The links span diverse areas including politics, psychology, economics, technology, and culture. Shorter summary

A critical review of Rutger Bregman's 'Humankind', analyzing its argument that human nature is fundamentally good, while highlighting both flaws and valuable insights in the book. Longer summary

This review critiques Rutger Bregman's book 'Humankind', which argues that human nature is fundamentally good. The reviewer analyzes Bregman's arguments, pointing out logical inconsistencies and cherry-picked data, while also acknowledging some valuable insights. The book covers topics such as human behavior during crises, the nature of empathy and power, and alternative approaches to management and democracy. The review concludes that while Bregman's thesis has flaws, his core message about trusting and respecting others more has merit. Shorter summary

Scott Alexander presents a detailed guide on depression, covering its causes, symptoms, and various treatment options, including lifestyle changes, therapies, medications, and other interventions. Longer summary

Scott Alexander provides a comprehensive guide on depression, covering its causes, symptoms, and various treatment options. He discusses lifestyle changes, therapies, medications, supplements, and other interventions like TMS and ECT. The post offers practical advice on how to approach treatment, including specific regimens for different situations, and guidelines on how long to continue treatment once it starts working. Shorter summary

Scott examines the bidirectional relationship between depression and sense of smell, exploring potential mechanisms and treatment implications. Longer summary

This post discusses the relationship between depression and olfactory function. It reviews studies showing that depressed people have a worse sense of smell, and people with impaired smell are more likely to be depressed. The post explores potential reasons for this connection, including depression's general effect on sensory acuity and the unique emotional salience of smell. It also discusses implications for depression treatment, including the effects of antidepressants on smell and potential olfactory-based therapies. The tone is analytical and somewhat humorous, with Scott critically examining various studies and hypotheses. Shorter summary

Scott Alexander examines the risks of Adderall use, analyzing medical, addiction, tolerance, and neurotoxicity concerns, concluding that the benefits outweigh the risks for well-informed patients. Longer summary

Scott Alexander explores the risks of Adderall use, examining medical risks, addiction potential, tolerance development, and possible neurotoxicity. He critically analyzes existing research and shares his clinical experience, ultimately concluding that while there are some concerning risks, they are not severe enough to stop prescribing stimulants to patients who might benefit from them, provided they are well-informed about the risks. Shorter summary

Scott Alexander challenges the popular interpretation of the Rat Park study, arguing that addiction is not solely caused by poor environments and emphasizing genetic factors in addiction susceptibility. Longer summary

Scott Alexander critiques the 'Rat Park' study and its popularized interpretation that drug addiction is primarily caused by poor social environments. He presents historical examples of addiction in seemingly happy or fortunate individuals, such as Ogedei Khan and Native Americans, to challenge this view. The post then discusses the genetic factors in addiction, citing twin studies and known genetic markers. Scott acknowledges that unhappiness likely contributes to drug use but argues that the relationship between environment and addiction is more complex than the Rat Park model suggests. He proposes a toy model where other sources of reward can help resist drug addiction, but maintains that biological interventions like deregulating suboxone and researching psychedelic therapy are more immediately effective for helping addicts. Shorter summary

Scott Alexander critiques a study on fathers' influence on sons' obesity, highlighting statistical flaws and misleading publicity, while exploring the broader challenge of identifying genuine parental effects. Longer summary

Scott Alexander critiques a study claiming fathers have a unique influence on their sons' obesity. He points out statistical flaws, particularly the lack of adjustment for multiple comparisons, and criticizes the university's press release for overstating the findings. The post also discusses the challenge of separating parental effects from genetic or intrauterine factors, and asks for examples of credible studies showing gender-specific parental effects. Shorter summary

Scott Alexander reviews a wide range of treatments for anxiety disorders, from lifestyle changes and therapy to medications and alternative remedies, emphasizing the importance of exploring multiple options. Longer summary

Scott Alexander provides an extensive overview of various treatments for anxiety disorders, covering diet and lifestyle changes, therapy options, conventional medications, and alternative treatments. He emphasizes the importance of lifestyle interventions like exercise and sleep, discusses the efficacy of cognitive-behavioral therapy and exposure therapy, and reviews various medication classes including SSRIs, SNRIs, and benzodiazepines. The post also explores alternative treatments like supplements and experimental drugs, concluding that while no single treatment stands out as extremely effective, there are many options available for those dealing with anxiety. Shorter summary

Scott Alexander examines various anti-wheat claims and pro-wheat evidence, concluding that while some concerns exist, current evidence generally supports wheat consumption for most people. Longer summary

Scott Alexander investigates the claims against wheat consumption, examining various arguments such as gluten sensitivity, intestinal permeability, wheat-derived opiates, connections to autism and schizophrenia, genetic modifications, and leptin resistance. He analyzes scientific studies and expert opinions, finding some claims to be partially true but often exaggerated or of uncertain significance. He also explores pro-wheat arguments, noting strong evidence for whole grain benefits but acknowledging potential confounders. The post concludes that while there are some concerns about wheat, the best evidence currently supports its inclusion in most people's diets. Shorter summary