A review of 'Great and Desperate Cures' by Elliot Valenstein, which examines the history of lobotomy and psychosurgery, explaining how tens of thousands of patients underwent dangerous brain operations from the 1930s-1950s despite poor evidence of effectiveness.

Scott Alexander presents his monthly collection of interesting links and developments across technology, science, culture, and policy, with personal commentary on each item.

Scott Alexander examines the problematic nature of emotional support animal letters, highlighting the ethical dilemmas for psychiatrists and the system's shortcomings.

Scott Alexander argues that schizophrenia should be described as predominantly genetic, addressing counterarguments and emphasizing the importance of this perspective for prevention strategies.

Scott Alexander examines a study challenging ketamine's effectiveness as an antidepressant, discussing potential confounding factors and maintaining his belief in ketamine's utility despite the study's results.

Scott Alexander criticizes new DEA regulations that restrict telemedicine prescriptions for controlled substances, arguing they will harm patients and legitimate practices while failing to prevent abuse.

Scott Alexander argues that a purely biological, apolitical taxonomy of mental disorders is impossible due to ethical and practical considerations that inevitably influence classifications.

Scott Alexander answers reader questions on various topics, including his projects, views, and personal preferences in a mailbag format.

Scott Alexander analyzes EA's approach to criticism, arguing that specific, targeted critiques are more valuable than vague, paradigmatic ones for driving real change.

Scott Alexander examines the Hearing Voices Movement, discussing its benefits and limitations in treating psychosis while emphasizing the need for a balanced approach to mental health care.

Scott Alexander provides a comprehensive guide on ketamine as a depression treatment, covering administration methods, effectiveness, safety, dosage, and potential side effects.

Scott Alexander investigates the optimal dosage of Lexapro, comparing it to other antidepressants and exploring the reasons behind its effectiveness at lower doses.

Scott Alexander critically examines a new theory on antidepressant mechanisms, expressing skepticism while acknowledging its potential significance if proven true.

Scott Alexander examines a theory proposing that depression, anxiety, and trauma are characterized by low precision of sensory evidence, leading to overreliance on negative priors.

Scott Alexander examines whether psychiatric conditions result from evolutionary failures or tradeoffs, proposing that most disorders involve a combination of both.

Scott Alexander examines mental disorders through the lens of dynamical systems theory, exploring how this perspective complements and contrasts with taxometric approaches.

Scott Alexander examines taxometrics in psychiatry, finding that most mental health conditions are dimensional rather than categorical, and discusses the implications for diagnosis and treatment.

Scott Alexander describes deleting his blog Slate Star Codex due to a doxxing threat, the aftermath, and his decision to return to blogging under his real name.

Scott Alexander introduces his new blog, Astral Codex Ten, centered around the concept of ṛta and exploring topics related to rationality, science, and human cognition.

Scott Alexander deletes his blog Slate Star Codex to prevent the New York Times from revealing his real name, citing professional and safety concerns.

Scott Alexander analyzes the PANDA Study, a large real-world antidepressant trial, discussing its methodology, results, and implications for understanding antidepressant efficacy.

Scott Alexander critiques Bryan Caplan's constraints vs preferences model of mental illness, proposing instead a goals vs urges framework that better explains both mental and physical health issues.

Scott Alexander argues that psychiatric diagnoses, while imperfect, are useful tools despite potentially combining multiple conditions with different causes.

Scott Alexander reviews 'The Body Keeps The Score', a book on PTSD, praising its historical context but criticizing its outdated science and uncritical embrace of alternative therapies.

Scott Alexander clarifies his intentions behind the APA photo-essay and cautions against overly negative interpretations of psychiatry or any professional field based on selective criticism.