Daniel Böttger describes his experience after brain surgery for cancer removed his right amygdala, resulting in the complete elimination of visceral fear, depression, and most suffering, while also causing some social difficulties and autism-like symptoms.

Scott explains why he's not interested in participating in the current wave of God debates on Substack, arguing that religious explanations fall into the same category as conspiracy theories by invoking "powerful hidden entities" to explain anomalies.

Scott argues the real distinction in psychology isn't between subfields but between settled science (like dopamine, brain localization, heritability) and breaking-news research, defending psychology's solid core against critics who conflate bad recent studies with the entire field.

A replication of a 2023 neuroscience study on brain entrainment and learning found that the original effect likely doesn't exist, revealing how the study obscured key issues through statistical averaging and highlighting how AI tools are democratizing scientific scrutiny.

Scott argues that dismissing AI as 'just a next-token predictor' is like dismissing humans as 'just reproduction machines' - both confuse the optimization process that shaped an entity with how that entity actually thinks.

Scott explains the Buddhist claim that 'life is suffering' through a temperature analogy: just as cold is merely the absence of heat, joy is merely less suffering, with nirvana being 'absolute zero suffering' rather than a neutral state.

A review of the synaptic plasticity and memory hypothesis arguing that it is insufficient to explain memory, and proposing a broader cellular processes and memory hypothesis that includes molecular and intracellular mechanisms.

A guest post defending the amyloid hypothesis of Alzheimer's disease, explaining why amyloid is likely the root cause despite recent criticism and discussing why early treatments have only been partially effective.

Scott investigates the correlation between intelligence and neuron count, exploring various theories before suggesting that more neurons allow for less polysemantic (overlapping) representations of concepts.

Scott Alexander examines the surprisingly broad effects of GLP-1 drugs like Ozempic, exploring their mechanisms and speculating on why they seem to impact so many different conditions.

Daniel Böttger proposes a new theory of consciousness as recursive reflections of neural oscillations, explaining qualia and suggesting experimental tests.

The post explores the Far Out Initiative's goal to eliminate suffering through biotechnology, inspired by a pain-free woman and David Pearce's philosophy.

Scott Alexander proposes that political hyperpartisanship might be a form of trauma, comparing PTSD symptoms to behaviors observed in political extremists.

Scott Alexander discusses recent breakthroughs in AI interpretability, explaining how researchers are beginning to understand the internal workings of neural networks.

Scott Alexander investigates the claim that children learn languages faster than adults, finding it partially true but more nuanced than commonly believed.

The review of 'The Mind of a Bee' examines the cognitive abilities of bees, raising questions about their intelligence and potential consciousness.

A review of 'Why Machines Will Never Rule the World', presenting its arguments against AGI based on complexity and computability, while critically examining its conclusions and relevance.

Scott explores GABA-A receptor subunits, their effects, and how various drugs interact with them, discussing potential for more selective drug development.

Scott summarizes interesting comments on his 'Rhythms of the Brain' book review, covering various aspects of brain waves and related topics.

Scott Alexander summarizes comments debating the reality and implications of jhanas, a meditative state of extreme bliss.

Scott Alexander examines the Buddhist concept of jhana, a blissful meditative state, through Nick Cammarata's experiences, exploring its implications for understanding pleasure and reinforcement.

Scott reviews 'Rhythms Of The Brain', exploring the nature and potential significance of brain waves in neuroscience and consciousness.

Scott Alexander explores various commenters' insights on the neuroscience of reward, happiness, and relationships, expanding on his original post about unpredictable rewards.

Scott Alexander analyzes a study showing Concerta improves ADHD children's attention but not their learning, and speculates on the reasons behind this unexpected result.

A review of Stanislas Dehaene's 'Consciousness and the Brain', discussing scientific findings on consciousness and their implications.