A review of the synaptic plasticity and memory hypothesis arguing that it is insufficient to explain memory, and proposing a broader cellular processes and memory hypothesis that includes molecular and intracellular mechanisms.

A detailed review of a 1995 paper introducing the PDAPP mouse model for Alzheimer's disease, examining how its limitations were overlooked and shaped decades of potentially misguided Alzheimer's research.

Scott Alexander examines recent studies on the Fraternal Birth Order Effect, finding evidence for a broader sibling birth order effect on homosexuality, though its exact nature and mechanism remain debated.

A review of 'The Anti-Politics Machine' by James Ferguson, discussing its critique of development projects and implications for Effective Altruism.

Scott Alexander shares 33 diverse links on topics ranging from history and science to technology and politics, offering brief summaries and commentary on each.

The post examines whether unimproved land value can be accurately assessed separately from buildings, a crucial aspect of Georgist land value taxation.

A compilation of 30 diverse links on various topics including science, history, technology, and culture, with brief commentaries by Scott Alexander.

Scott Alexander presents a monthly collection of 42 diverse links covering topics from science, politics, culture, and technology, highlighting interesting findings and current events.

Scott Alexander examines the development and effectiveness of vilazodone and vortioxetine, two antidepressants designed to work faster and better than SSRIs, but which ultimately failed to live up to expectations.

Scott Alexander examines the impact of media coverage on fringe beliefs like creationism, suggesting that reduced coverage doesn't necessarily lead to their spread.

A vegetarian and meat-eater collaborate to analyze the impacts of eating meat, concluding that reduced consumption is beneficial but not as clear-cut as some might think.

This Adversarial Collaboration Contest entry examines the evidence and debates surrounding transgender children transitioning, covering desistence rates, social transitioning, puberty blockers, and mental health outcomes.

TracingWoodgrains and Michael Pershan analyze the effectiveness of ability grouping, acceleration, and personalization software in serving advanced students in the education system.

Scott Alexander examines conflicting narratives about cancer treatment progress, analyzing data to show that while some improvements are due to social factors, there's evidence of genuine advancements in cancer treatment and outcomes.

Scott Alexander explores Hallucinogen Persisting Perception Disorder (HPPD) and other conditions where drugs cause permanent effects, discussing potential mechanisms and their implications.

Scott Alexander discusses the British junior doctors' strike, detailing the harsh working conditions and systemic issues that likely led to it, based on his experience in a similar system.

Scott Alexander examines why early psychedelic researchers often became eccentric, proposing that psychedelics might permanently increase openness to unusual ideas.

Scott shares diverse links ranging from optical illusions and Bitcoin drama to educational research and medical controversies, with commentary on methodology and social implications.

Scott shares and comments on various links covering science, politics, and culture, with topics ranging from automation's effect on employment to psychology's replication crisis.

Scott examines evidence for racial bias in the US criminal justice system, finding some bias in certain areas but not others, and concluding that claims of pervasive racism are overstated.

Scott Alexander examines the effectiveness of Alcoholics Anonymous, finding it and other treatments only marginally better than no treatment, based on flawed and inconclusive studies.

Scott Alexander shares a diverse collection of interesting links with brief commentaries, covering topics from education and politics to science and technology.

Ozy Frantz provides a detailed critique of common 'manosphere' beliefs, particularly those of blogger Heartiste, using scientific studies and logical arguments to counter claims about human sexuality and dating.