A review of 'Great and Desperate Cures' by Elliot Valenstein, which examines the history of lobotomy and psychosurgery, explaining how tens of thousands of patients underwent dangerous brain operations from the 1930s-1950s despite poor evidence of effectiveness. Longer summary

The post reviews 'Great and Desperate Cures' (1986) by psychologist Elliot Valenstein, exploring how lobotomy became widespread despite its horrific consequences. The review details the procedure itself (inserting an ice-pick-like instrument through the eye socket into the brain), then examines six factors Valenstein identifies for its acceptance: desperate patients and families, physician ambition (especially Egas Moniz and Walter Freeman), uncritical acceptance by researchers and media, territorial disputes between medical specialties, and cold economics. The post includes extensive details about key figures, particularly Freeman's aggressive promotion of transorbital lobotomy and his traveling surgery roadshows. It discusses patient outcomes, the lack of theoretical justification, media hype, and the procedure's eventual replacement by psychoactive drugs. The review concludes by reflecting on modern parallels and the tragic story of Howard Dully, lobotomized at age twelve, arguing that while Freeman likely had good intentions, the safeguards that might have prevented such harm were inadequate then and remain concerning today. Shorter summary

Scott presents Plan A, a detailed roadmap by Daniel Kokotajlo's AI Futures Project proposing a US-China regulatory agreement to safely advance AI to genius-level systems in the 2030s, solve alignment during a controlled pause, then achieve aligned superintelligence by 2040. Longer summary

Scott introduces Plan A, a detailed roadmap created by Daniel Kokotajlo and the AI Futures Project for navigating the AI transition safely. The plan envisions a trustless regulatory agreement between the US and China built on controlling chip supply and auditing data centers, followed by a 'golden mean' approach where both countries rapidly advance to top-human-genius-level AI while pausing before superintelligence. During this pause in the 2030s, billions of genius-level AIs would solve alignment and other major problems while being kept in controlled environments, eventually leading to fully aligned superintelligence around 2040 that helps chart humanity's future. The post frames this as offering a positive vision that satisfies both safety concerns and accelerationist goals through triple-digit GDP growth and rapid problem-solving. Shorter summary

A review of the synaptic plasticity and memory hypothesis arguing that it is insufficient to explain memory, and proposing a broader cellular processes and memory hypothesis that includes molecular and intracellular mechanisms. Longer summary

The post reviews the synaptic plasticity and memory (SPM) hypothesis, which claims that learning and memory are stored in changes to synaptic weights between neurons. Through several compelling examples, from cannibalism rituals to heart transplant stories and single-cell learning, the author argues that while the SPM hypothesis has been productive, it is incomplete and partially wrong. The post presents evidence that memory can be stored through non-synaptic mechanisms, and proposes an alternative called the cellular processes and memory (CPM) hypothesis, which suggests memory storage involves multiple molecular and intracellular processes beyond just synaptic weights. Shorter summary

Scott Alexander reports on the Progress Studies Conference, discussing advances in energy, AI, housing policy, and other fields, with an overall optimistic tone about recent developments and potential for future progress. Longer summary

Scott Alexander recounts his experience at the Progress Studies Conference, which focused on various technological and social advancements. The conference covered topics such as energy (particularly solar and nuclear power), politics and regulation, AI, YIMBY movement, self-driving cars, and other areas of potential progress. The overall mood was optimistic about recent developments in these fields, with many speakers highlighting how regulatory changes could accelerate progress. Scott notes that while the conference itself may not be directly responsible for recent advances, it reflects a growing awareness of the importance of technological progress and the need to address regulatory barriers. Shorter summary

Scott Alexander defends the practice of looking to idealized traditions for inspiration, arguing it's a common and useful human approach to creativity and innovation. Longer summary

Scott Alexander discusses the concept of tradition and how it's often misunderstood or criticized. He argues that references to the past or tradition are often just 'pointers' to specific aspects people appreciate, not necessarily an endorsement of everything from that era. He challenges the idea that past cultures didn't look back to idealized histories, providing examples from various periods showing how looking to an idealized past has been a common human practice. Scott suggests that using tradition as inspiration can be a psychologically easier way to introduce new ideas or practices than presenting them as entirely original. Shorter summary

Scott Alexander examines optimistic and pessimistic scenarios for AI risk, weighing the potential for intermediate AIs to help solve alignment against the threat of deceptive 'sleeper agent' AIs. Longer summary

Scott Alexander discusses the varying estimates of AI extinction risk among experts and presents his own perspective, balancing optimistic and pessimistic scenarios. He argues that intermediate AIs could help solve alignment problems before a world-killing AI emerges, but also considers the possibility of 'sleeper agent' AIs that pretend to be aligned while waiting for an opportunity to act against human interests. The post explores key assumptions that differentiate optimistic and pessimistic views on AI risk, including AI coherence, cooperation, alignment solvability, superweapon feasibility, and the nature of AI progress. Shorter summary

A review of Guy Debord's 'The Society of the Spectacle', examining its critique of capitalism and mass media, and relating its ideas to modern issues. Longer summary

This review examines Guy Debord's 'The Society of the Spectacle', a Marxist critique of capitalism and mass media. The reviewer summarizes Debord's key ideas about how spectacle dominates modern society, commodifies all aspects of life, and creates a false reality. The review also covers Debord's later comments on the book, relating his ideas to current issues like social media, fake news, and information warfare. While acknowledging the book's insights, the reviewer ultimately takes a more moderate stance on capitalism and technology's impacts. Shorter summary

A review of Richard Hanania's book arguing that public choice theory, not grand strategy, explains US foreign policy decisions and their often devastating consequences. Longer summary

This book review discusses Richard Hanania's 'Public Choice Theory And The Illusion Of Grand Strategy', which argues that public choice theory better explains US foreign policy than the unitary actor model. The review covers the book's key arguments, including how special interest groups shape foreign policy, the incoherence of American interventions, and the devastating effects of sanctions. It also explores the book's relevance to current events like the Russian invasion of Ukraine and potential implications for nuclear security and effective altruism. Shorter summary

Scott analyzes motivated reasoning as misapplied reinforcement learning, explaining how it might arise from the brain's mixture of reinforceable and non-reinforceable architectures. Longer summary

Scott explores the concept of motivated reasoning as misapplied reinforcement learning in the brain. He contrasts behavioral brain regions that benefit from hedonic reinforcement learning with epistemic regions where such learning would be detrimental. The post discusses how this distinction might explain phenomena like 'ugh fields' and motivated reasoning, especially in novel situations like taxes or politics where brain networks might be placed on a mix of reinforceable and non-reinforceable architectures. Scott suggests this model could explain why people often confuse what is true with what they want to be true. Shorter summary

The review analyzes Robert Ellickson's 'Order Without Law', which argues that close-knit communities often develop welfare-maximizing social norms that supersede formal laws. Longer summary

This book review examines 'Order Without Law: How Neighbors Settle Disputes' by Robert Ellickson, which explores how social norms often supersede formal laws in close-knit communities. The review provides a detailed analysis of Ellickson's main hypothesis: that members of close-knit groups develop norms that maximize aggregate welfare in their everyday interactions. It discusses various case studies, including cattle ranchers in Shasta County and whalers, and critically examines the strengths and limitations of Ellickson's arguments. Shorter summary

Scott reviews 'Ages of Discord', which applies cyclic theories of civilizational rise and fall to modern America, finding the data interesting but the core theory questionable. Longer summary

Scott reviews Peter Turchin's book 'Ages of Discord', which attempts to apply the demographic-structural theory of civilizational cycles to modern America. The book presents data showing cyclic patterns in various societal indicators over the past 200+ years, including two main cycles: a long 150-year cycle of national growth and decline, and a shorter 40-60 year cycle of instability. Scott examines the data, theory, and potential problems with applying this pre-industrial model to a modern economy. While finding the data interesting, he is skeptical of some of the theoretical explanations and notes several issues with the arguments. He concludes that while the book provides some valuable concepts and historical information, its core cyclical theory remains questionable. Shorter summary

Scott Alexander presents a diverse collection of links and brief commentary on topics ranging from historical anecdotes to recent scientific studies and political developments. Longer summary

This post is a collection of various links and brief commentary on diverse topics. It covers historical anecdotes, scientific studies, political developments, and cultural phenomena. The post touches on subjects like vegetarian activism, Supreme Court changes, AI alignment, and Silicon Valley culture. Scott Alexander provides concise summaries and occasional personal opinions on these wide-ranging topics, often with a touch of humor or irony. Shorter summary

Scott Alexander celebrates Slate Star Codex's fifth anniversary by thanking the many people who have contributed to the blog's success and growth. Longer summary

Scott Alexander celebrates the fifth anniversary of Slate Star Codex, thanking numerous individuals and groups who have contributed to the blog's success. He expresses gratitude to those who have helped with technical aspects, moderation, organization of meetups, and content creation. Scott also thanks his supporters, advertisers, and even his critics for their decency. He acknowledges the value of the blog's community, particularly in comments and survey participation, which has enabled interesting research findings. Shorter summary

Scott Alexander criticizes Ted Chiang's article that compares AI risk to capitalism, arguing that the analogy is flawed and the reasoning behind it is unsound. Longer summary

Scott Alexander critiques Ted Chiang's article comparing AI risk to capitalism, arguing that the comparison is flawed and the reasoning unsound. He points out that AI risk concerns originated from academics, not just Silicon Valley, and that drawing analogies between scientific concepts and social phenomena doesn't disprove the original concept. Scott also criticizes Chiang's use of psychological projection to explain AI fears, noting the dangers of amateur psychoanalysis. He concludes by emphasizing that this approach to risk assessment is inappropriate for potentially catastrophic issues. Shorter summary

Scott Alexander offers ten tips for effective nonfiction writing, emphasizing structure, variety, flow, and persuasion techniques. Longer summary

Scott Alexander provides advice on nonfiction writing, covering topics such as text structure, variety in writing, maintaining flow of ideas, repetition, humor, concrete examples, persuasion techniques, anticipating counterarguments, and using concept handles. He emphasizes the importance of developing instincts and not forcing the application of these rules. Shorter summary

A writer pitches increasingly absurd zombie story ideas to an editor who dismisses them all as 'done', ending with a twist revealing the editor is a zombie. Longer summary

This satirical story depicts a conversation between a writer and an editor about a proposed zombie story. The writer tries to pitch various zombie story ideas, but the editor repeatedly dismisses them as 'done', highlighting the oversaturation of the zombie genre. The writer becomes increasingly desperate, proposing more and more outlandish ideas, all of which have supposedly been done. The story ends with a twist revealing that the editor is actually a zombie, ironically embodying the very trope being criticized. Shorter summary

Scott presents a humorous list of fictional drugs banned by the FDA, each with unexpected and often ironic consequences. Longer summary

This post is a satirical list of fictional drugs banned by the FDA, each with a unique profile and an often ironic or paradoxical reason for its ban. The drugs range from treatments for pre-traumatic stress disorder to antibiotics for intelligent bacteria. Each drug description includes its intended use and the unexpected consequences that led to its ban. The post uses humor and creativity to explore themes of unintended consequences in medicine, the complexities of drug development, and the sometimes absurd nature of bureaucratic decision-making. Shorter summary