Scott examines the rise of AI superforecasters that now match or exceed top human forecasters, explores how they work and their current performance, and analyzes implications for decision-making, prediction markets, and the future role of AI opinions.

Scott announces the results of the 2025 ACX Grants round, awarding $1.5 million to 42 projects out of 654 applications, covering areas from genetic engineering and disease prevention to AI safety and educational reform.

Scott Alexander refutes Stephen Skolnick's theory that schizophrenia is caused by gut microbes rather than genetics, showing why the evidence better supports schizophrenia being a complex genetic neurodevelopmental disorder.

A diverse collection of news items, studies, and interesting facts from November 2024, covering topics from scientific discoveries to cultural phenomena.

Scott Alexander examines how compounding pharmacies are producing cheaper versions of GLP-1 agonist drugs, exploring the economics, safety, and future implications of this practice.

A review of 'The Family That Couldn't Sleep' by D. T. Max, discussing its exploration of prion diseases and their impact, with updated perspectives on the book's conclusions.

Scott Alexander challenges Robin Hanson's claim that medicine doesn't work by analyzing health insurance studies and presenting evidence of medicine's effectiveness.

A collection of 47 diverse links and news items covering topics from religious practices to AI developments, with brief commentary on many items.

Scott Alexander addresses feedback on his post about bisexuality and Long COVID, discussing alternative explanations and defending his methodology.

Scott Alexander presents a diverse collection of 49 links and brief commentaries on various topics, ranging from cultured meat to AI developments and current events.

Scott Alexander responds to critiques of his 2021 ivermectin analysis, acknowledging some errors but maintaining his conclusion that ivermectin likely doesn't work for COVID-19.

Scott Alexander analyzes the potential role of psychopharmacology in the FTX crash, discussing medications used by SBF and others, and their possible effects on decision-making.

Scott Alexander shares 33 diverse links on topics ranging from history and science to technology and politics, offering brief summaries and commentary on each.

Scott Alexander examines obscure pregnancy interventions that may improve child outcomes, rating them by evidence quality and potential impact.

Scott Alexander examines Zulresso and Zuranolone, two neurosteroid drugs for postpartum depression, discussing their efficacy, challenges, and potential future applications.

Scott Alexander shares 34 varied links and pieces of information on topics including science, history, politics, and technology, with brief commentary on many items.

Scott Alexander analyzes ivermectin studies for COVID-19, finding most positive results likely due to methodological flaws, fraud, or confounding by parasitic infections.

A compilation of 30 diverse links on various topics including science, history, technology, and culture, with brief commentaries by Scott Alexander.

Scott Alexander examines the current research on Long COVID, analyzing its prevalence, symptoms, and potential impacts to assess personal risk and societal implications.

Scott examines the relationship between sleep, synaptic homeostasis, and depression, exploring how sleep deprivation temporarily alleviates depression symptoms.

Scott Alexander examines the history, chemistry, and efficacy of various amphetamine-based ADHD medications, comparing their strengths and weaknesses.

Scott Alexander examines the historical link between gout and achievement, ultimately finding the evidence unconvincing despite some intriguing connections.

Scott examines the bidirectional relationship between depression and sense of smell, exploring potential mechanisms and treatment implications.

Scott examines how the 5-HTTLPR gene was wrongly linked to depression for years, discussing the implications for psychiatric research and genetic testing products.

Scott Alexander critically examines studies on preschool effects, finding mixed and inconsistent evidence for long-term benefits.