Scott examines the rise of AI superforecasters that now match or exceed top human forecasters, explores how they work and their current performance, and analyzes implications for decision-making, prediction markets, and the future role of AI opinions. Longer summary

Scott discusses the emergence of AI superforecasters that are now matching or slightly exceeding top human forecasters in prediction accuracy. He describes how these AI systems work (using scaffolding around frontier models like GPT/Claude), demonstrates their use with examples from FutureSearch and Preseen, and analyzes their performance on platforms like Metaculus where they're competing in tournaments against humans. The post explores both near-term implications (AI forecasters being easier to access than human superforecasters, potentially influencing policy and business decisions) and longer-term possibilities (AI forecasters serving as an 'opinion layer' for AI systems, transformation of prediction markets into AI-vs-AI competitions). Scott argues these developments could be genuinely beneficial, giving people access to superhuman forecasting ability just as AI threatens other aspects of society. Shorter summary

Scott announces the results of the 2025 ACX Grants round, awarding $1.5 million to 42 projects out of 654 applications, covering areas from genetic engineering and disease prevention to AI safety and educational reform. Longer summary

Scott Alexander announces the results of the 2025 ACX Grants program, which received 654 applications and funded 42 projects across diverse areas including global health, AI safety, metascience, animal welfare, and development economics. The grants range from $5,000 to $150,000 and support initiatives like genetically engineered nutritious corn, screwworm eradication, lead-acid battery recycling programs, organ donation improvement, AI bias research, and various biosecurity and pandemic prevention projects. Scott thanks the funders, Manifund team, and numerous expert evaluators who helped assess applications, and notes that some projects remain in stealth mode. The post concludes with extensive credits to contributors and mentions that the next grants round will likely occur in late 2026 or early 2027. Shorter summary

Scott Alexander refutes Stephen Skolnick's theory that schizophrenia is caused by gut microbes rather than genetics, showing why the evidence better supports schizophrenia being a complex genetic neurodevelopmental disorder. Longer summary

Scott Alexander responds to Stephen Skolnick's theory that schizophrenia is caused by gut microbes rather than genetics. He systematically dismantles Skolnick's arguments by showing that twin concordance rates are exactly what we'd expect from a genetic condition, that microbiological inheritance patterns don't match schizophrenia inheritance patterns, and that the gut bacteria evidence cited was likely caused by antipsychotic medication rather than being causative. He concludes by explaining why schizophrenia is best understood as a complex neurodevelopmental disorder with multiple contributing factors rather than having a single cause. Shorter summary

A diverse collection of news items, studies, and interesting facts from November 2024, covering topics from scientific discoveries to cultural phenomena. Longer summary

This post is a compilation of various news items, studies, and interesting facts from November 2024. It covers a wide range of topics including scientific discoveries, political events, technological advancements, cultural phenomena, and historical anecdotes. The post is structured as a numbered list, with each item briefly summarizing a piece of news or information. Some notable items include a new schizophrenia drug approval, YouGov polling results on various historical figures, findings on genetic IQ changes over time, and updates on AI technology and its implications. Shorter summary

Scott Alexander examines how compounding pharmacies are producing cheaper versions of GLP-1 agonist drugs, exploring the economics, safety, and future implications of this practice. Longer summary

Scott Alexander discusses the 'compounding loophole' that allows compounding pharmacies to produce cheaper versions of GLP-1 agonist drugs like semaglutide (Ozempic). He explains how these pharmacies operate, the cost differences, safety concerns, and potential future implications. The post covers the legal basis for this practice during drug shortages, the impact on drug manufacturers like Novo Nordisk, and speculates on what might happen when the shortage ends. Scott also touches on the broader implications for drug pricing and availability. Shorter summary

A review of 'The Family That Couldn't Sleep' by D. T. Max, discussing its exploration of prion diseases and their impact, with updated perspectives on the book's conclusions. Longer summary

This review discusses 'The Family That Couldn't Sleep' by D. T. Max, a book about prion diseases published in 2006. The review covers the book's exploration of various prion diseases, including fatal familial insomnia, kuru, mad cow disease, and chronic wasting disease. It highlights the book's focus on the historical, scientific, and cultural aspects of these diseases, as well as the key figures involved in prion research. The reviewer also provides updated information and critiques some of the book's conclusions in light of more recent research. Shorter summary

Scott Alexander challenges Robin Hanson's claim that medicine doesn't work by analyzing health insurance studies and presenting evidence of medicine's effectiveness. Longer summary

Scott Alexander critiques Robin Hanson's claim that medicine doesn't work, analyzing three major health insurance experiments (RAND, Oregon, and Karnataka) and other studies. He argues that these studies are underpowered to detect medication effects and don't support Hanson's conclusion, citing evidence of medicine's effectiveness in improving survival rates for various diseases. Shorter summary

A collection of 47 diverse links and news items covering topics from religious practices to AI developments, with brief commentary on many items. Longer summary

This post is a collection of 47 diverse links and news items covering various topics. It includes discussions on religious practices, video games, political trends, scientific studies, AI developments, economic analyses, historical anecdotes, and cultural phenomena. The author provides brief commentary on many of the items, often with a mix of humor and critical analysis. The links range from academic studies and economic reports to quirky historical facts and contemporary cultural observations. Shorter summary

Scott Alexander addresses feedback on his post about bisexuality and Long COVID, discussing alternative explanations and defending his methodology. Longer summary

Scott Alexander responds to comments on his previous post about the correlation between bisexuality and Long COVID. He addresses alternative explanations, concerns about sample size and methodology, the nature of psychosomatic illness, and various other points raised by readers. Scott maintains that while the association exists in the data, the cause remains uncertain and could be due to various factors including response patterns, biological differences, or a combination of organic and psychosomatic elements. Shorter summary

Scott Alexander presents a diverse collection of 49 links and brief commentaries on various topics, ranging from cultured meat to AI developments and current events. Longer summary

This post is a collection of 49 diverse links and brief commentaries on various topics, including cultured meat, government policies, scientific studies, historical anecdotes, AI developments, and current events. The author, Scott Alexander, provides his thoughts and observations on each item, often with a mix of humor, skepticism, and analysis. The links cover a wide range of subjects from technology and economics to politics and culture, reflecting the broad interests of the blog's readership. Shorter summary

Scott Alexander responds to critiques of his 2021 ivermectin analysis, acknowledging some errors but maintaining his conclusion that ivermectin likely doesn't work for COVID-19. Longer summary

Scott Alexander responds to Alexandros Marinos' critique of his 2021 post on ivermectin studies, addressing points about individual studies, meta-analysis methods, publication bias, and new evidence since 2021. He acknowledges some mistakes in his original analysis but maintains his overall conclusion that ivermectin is likely ineffective for COVID-19. Shorter summary

Scott Alexander analyzes the potential role of psychopharmacology in the FTX crash, discussing medications used by SBF and others, and their possible effects on decision-making. Longer summary

Scott Alexander discusses the psychopharmacology aspects of the FTX crash, focusing on the medications Sam Bankman-Fried (SBF) and other FTX employees may have been taking. He examines claims about SBF's use of Emsam (selegiline), modafinil, and other stimulants, explaining their effects and potential risks. Scott also critiques the actions of FTX's company psychiatrist and discusses the broader implications of stimulant use in high-pressure work environments. The post ends with Scott's personal anecdote about testifying as an expert witness. Shorter summary

Scott Alexander shares 33 diverse links on topics ranging from history and science to technology and politics, offering brief summaries and commentary on each. Longer summary

This post is a collection of 33 diverse links and brief summaries on various topics, including history, science, technology, politics, and culture. Scott Alexander covers a wide range of subjects, from the history of garlic and magnets to AI-generated art, touching on topics like language models, Nobel laureates by state, ivermectin studies, nuclear weapons, and unusual legal cases. The post showcases interesting facts, recent studies, and thought-provoking ideas across multiple disciplines. Shorter summary

Scott Alexander examines obscure pregnancy interventions that may improve child outcomes, rating them by evidence quality and potential impact. Longer summary

Scott Alexander reviews various obscure pregnancy interventions that could potentially improve child outcomes, particularly IQ. He rates them in tiers based on evidence strength and potential impact, with Tier 1 being most strongly supported. Key interventions discussed include embryo selection, choline supplementation, avoiding stress and certain substances, and optimizing birth timing. He emphasizes these are extreme measures not meant to induce guilt, and that standard pregnancy advice is still most important. Shorter summary

Scott Alexander examines Zulresso and Zuranolone, two neurosteroid drugs for postpartum depression, discussing their efficacy, challenges, and potential future applications. Longer summary

Scott Alexander discusses Zulresso (allopregnanolone) and Zuranolone, two related drugs for treating postpartum depression. He explains their mechanisms, efficacy, and the challenges in their development and usage. The post covers the history of allopregnanolone research, its connection to GABA and hormones, clinical trials, and potential future applications. Scott also discusses the high cost of Zulresso, its limited availability, and the mixed results of Zuranolone in treating regular depression and anxiety. The post ends with predictions about the future of these drugs and related research. Shorter summary

Scott Alexander shares 34 varied links and pieces of information on topics including science, history, politics, and technology, with brief commentary on many items. Longer summary

This post is a collection of 34 diverse links and snippets of information on various topics. It covers subjects ranging from Jeff Bezos' biological father, to studies on Christianity's growth, to climate change discussions, to updates on AI progress. The post also includes commentary on current events like the University of Austin controversy and political polling trends. Many of the links discuss recent scientific studies or historical anecdotes, often with Scott's brief analysis or opinion added. Shorter summary

Scott Alexander analyzes ivermectin studies for COVID-19, finding most positive results likely due to methodological flaws, fraud, or confounding by parasitic infections. Longer summary

Scott Alexander provides an in-depth analysis of ivermectin studies for COVID-19 treatment, examining methodological issues, potential fraud, and confounding factors. He concludes that ivermectin likely doesn't significantly reduce COVID mortality except potentially in areas with high parasitic worm infections. The post explores broader issues around scientific credibility, fraud detection, and public trust in science. Shorter summary

A compilation of 30 diverse links on various topics including science, history, technology, and culture, with brief commentaries by Scott Alexander. Longer summary

This post is a collection of 30 diverse links and brief discussions on various topics. It covers a wide range of subjects including scientific findings, historical anecdotes, technological developments, cultural phenomena, and current events. The post touches on topics such as oil spills, architecture, IQ research, chronic pain therapy, alcohol consumption, AI safety, and more. Scott Alexander provides short commentaries or explanations for each link, often adding his own insights or connecting the information to broader themes. Shorter summary

Scott Alexander examines the current research on Long COVID, analyzing its prevalence, symptoms, and potential impacts to assess personal risk and societal implications. Longer summary

Scott Alexander reviews the current research on Long COVID, examining its prevalence, symptoms, duration, and impact on different groups. He explores various studies, discusses potential mechanisms, and evaluates the psychosomatic argument. The post concludes with an assessment of personal risk and comparisons to other post-viral syndromes, emphasizing the uncertainties still surrounding Long COVID. Shorter summary

Scott examines the relationship between sleep, synaptic homeostasis, and depression, exploring how sleep deprivation temporarily alleviates depression symptoms. Longer summary

Scott Alexander discusses a phenomenon where sleep deprivation temporarily alleviates depression, and explores the potential connection between sleep, synaptic homeostasis, and depression. He reviews the synaptic homeostasis hypothesis of sleep, which suggests that sleep helps renormalize synaptic connections, and connects this to research indicating that depression involves a deficit of synapses. The post then delves into various subtopics related to this theory, including the roles of REM and non-REM sleep, the effects of TMS and electroconvulsive therapy, and potential connections to circadian rhythms and bipolar disorder. Shorter summary

Scott Alexander examines the history, chemistry, and efficacy of various amphetamine-based ADHD medications, comparing their strengths and weaknesses. Longer summary

Scott Alexander explores the history and differences between various amphetamine-based ADHD medications. He traces the origins of Adderall to a 1950s diet pill, then compares it to other drugs like Dexedrine, Vyvanse, Evekeo, and Desoxyn (methamphetamine). The post discusses the chemical differences, patient preferences, and effectiveness of these medications, noting that pure d-amphetamine (Dexedrine) seems generally superior to the Adderall mixture. Scott also touches on the controversy surrounding methamphetamine use in ADHD treatment, explaining that the main differences between therapeutic use and abuse are dosage and administration method rather than inherent properties of the drug. Shorter summary

Scott Alexander examines the historical link between gout and achievement, ultimately finding the evidence unconvincing despite some intriguing connections. Longer summary

Scott Alexander explores the historical association between gout and high achievement, discussing a theory that high uric acid levels might contribute to success. He examines the biological basis for this idea, comparing uric acid to caffeine and theacrine. However, after reviewing several studies, Scott concludes that the evidence for this theory is weak and inconsistent. He then discusses more recent research linking uric acid to mood disorders, particularly mania, but suggests that more research is needed before any firm conclusions can be drawn. Shorter summary

Scott examines the bidirectional relationship between depression and sense of smell, exploring potential mechanisms and treatment implications. Longer summary

This post discusses the relationship between depression and olfactory function. It reviews studies showing that depressed people have a worse sense of smell, and people with impaired smell are more likely to be depressed. The post explores potential reasons for this connection, including depression's general effect on sensory acuity and the unique emotional salience of smell. It also discusses implications for depression treatment, including the effects of antidepressants on smell and potential olfactory-based therapies. The tone is analytical and somewhat humorous, with Scott critically examining various studies and hypotheses. Shorter summary

Scott examines how the 5-HTTLPR gene was wrongly linked to depression for years, discussing the implications for psychiatric research and genetic testing products. Longer summary

This post discusses the history and eventual debunking of the 5-HTTLPR gene's supposed role in depression. Initially, numerous studies claimed to find links between 5-HTTLPR and various mental health conditions, interactions with stress, and even antidepressant efficacy. However, a recent large-scale study by Border et al. found no evidence for these claims, suggesting that hundreds of previous studies were likely false positives. The post explores the implications of this finding, including concerns about the reliability of psychiatric research, the tendency for studies to reinforce existing beliefs, and the questionable validity of pharmacogenomic testing products that rely on genes like 5-HTTLPR. Shorter summary

Scott Alexander critically examines studies on preschool effects, finding mixed and inconsistent evidence for long-term benefits. Longer summary

Scott Alexander reviews multiple studies on the long-term effects of preschool programs like Head Start. While early studies showed fade-out of test score gains, some found lasting benefits in adult outcomes. However, Scott finds inconsistencies between studies in which subgroups benefit and on which outcomes. He also notes concerns about potential p-hacking and researcher degrees of freedom. Ultimately, Scott concludes that the evidence is mixed - it permits believing preschool has small positive effects, but does not force that conclusion. He estimates 60% odds preschool helps in ways suggested by the studies, 40% odds it's useless. Shorter summary