Scott Alexander responds to comments on his COVID-19 origins debate post, addressing criticisms and maintaining his support for the zoonosis theory. Longer summary

Scott Alexander provides a detailed response to comments and criticisms of his previous post on the COVID-19 origins debate. He addresses arguments against zoonosis, clarifies misunderstandings, and discusses the methodologies used by various parties in the debate. He maintains his position favoring zoonosis over lab leak, while acknowledging the complexity of the issue and the ongoing nature of the debate. Shorter summary

Scott Alexander argues that schizophrenia should be described as predominantly genetic, addressing counterarguments and emphasizing the importance of this perspective for prevention strategies. Longer summary

Scott Alexander argues that it's fair and accurate to describe schizophrenia as predominantly genetic. He responds to various arguments against this characterization, comparing the situation to how we discuss smoking causing lung cancer. Scott emphasizes that while environmental factors play a role, genetic factors account for the majority of variance in schizophrenia risk. He argues that acknowledging the genetic nature of schizophrenia is important for developing effective prevention strategies, such as polygenic screening, rather than focusing solely on hard-to-control environmental factors. Shorter summary

Scott Alexander addresses feedback on his post about bisexuality and Long COVID, discussing alternative explanations and defending his methodology. Longer summary

Scott Alexander responds to comments on his previous post about the correlation between bisexuality and Long COVID. He addresses alternative explanations, concerns about sample size and methodology, the nature of psychosomatic illness, and various other points raised by readers. Scott maintains that while the association exists in the data, the cause remains uncertain and could be due to various factors including response patterns, biological differences, or a combination of organic and psychosomatic elements. Shorter summary

Scott Alexander examines obscure pregnancy interventions that may improve child outcomes, rating them by evidence quality and potential impact. Longer summary

Scott Alexander reviews various obscure pregnancy interventions that could potentially improve child outcomes, particularly IQ. He rates them in tiers based on evidence strength and potential impact, with Tier 1 being most strongly supported. Key interventions discussed include embryo selection, choline supplementation, avoiding stress and certain substances, and optimizing birth timing. He emphasizes these are extreme measures not meant to induce guilt, and that standard pregnancy advice is still most important. Shorter summary

Scott Alexander examines Zulresso and Zuranolone, two neurosteroid drugs for postpartum depression, discussing their efficacy, challenges, and potential future applications. Longer summary

Scott Alexander discusses Zulresso (allopregnanolone) and Zuranolone, two related drugs for treating postpartum depression. He explains their mechanisms, efficacy, and the challenges in their development and usage. The post covers the history of allopregnanolone research, its connection to GABA and hormones, clinical trials, and potential future applications. Scott also discusses the high cost of Zulresso, its limited availability, and the mixed results of Zuranolone in treating regular depression and anxiety. The post ends with predictions about the future of these drugs and related research. Shorter summary

Scott Alexander responds to comments on his ivermectin article, discussing criticisms, the worms hypothesis, vaccine skepticism, and journalism quality. Longer summary

This post highlights comments on Scott Alexander's previous article about ivermectin as a potential COVID-19 treatment. Scott responds to criticisms from ivmmeta.com, discusses the worms hypothesis with various commenters, addresses concerns about the TOGETHER trial, and shares perspectives on vaccine skepticism and journalism quality. He also reflects on his own writing process compared to traditional journalism. Shorter summary

Scott Alexander analyzes ivermectin studies for COVID-19, finding most positive results likely due to methodological flaws, fraud, or confounding by parasitic infections. Longer summary

Scott Alexander provides an in-depth analysis of ivermectin studies for COVID-19 treatment, examining methodological issues, potential fraud, and confounding factors. He concludes that ivermectin likely doesn't significantly reduce COVID mortality except potentially in areas with high parasitic worm infections. The post explores broader issues around scientific credibility, fraud detection, and public trust in science. Shorter summary

Scott investigates the claim that cold-related deaths account for 10% of global mortality, exploring various factors and potential impacts of global warming on death rates. Longer summary

Scott Alexander explores the surprising claim that cold-related deaths account for nearly 10% of all deaths globally. He investigates various studies and data sources to understand this phenomenon, discussing the differences between cold-related and winter-related deaths, regional variations in mortality rates, and potential mechanisms behind these deaths. The post delves into the complexities of adapting to different climates, the role of influenza in winter mortality, and cardiovascular effects of cold weather. Finally, Scott examines the potential impact of global warming on mortality rates, finding that most scientific analyses predict a net increase in deaths despite the reduction in cold-related mortality. Shorter summary

Scott Alexander presents a detailed guide on depression, covering its causes, symptoms, and various treatment options, including lifestyle changes, therapies, medications, and other interventions. Longer summary

Scott Alexander provides a comprehensive guide on depression, covering its causes, symptoms, and various treatment options. He discusses lifestyle changes, therapies, medications, supplements, and other interventions like TMS and ECT. The post offers practical advice on how to approach treatment, including specific regimens for different situations, and guidelines on how long to continue treatment once it starts working. Shorter summary

Scott Alexander investigates the optimal dosage of Lexapro, comparing it to other antidepressants and exploring the reasons behind its effectiveness at lower doses. Longer summary

Scott Alexander explores the question of the right dose for Lexapro (escitalopram), an antidepressant. He examines official recommendations, compares Lexapro to other SSRIs, and investigates why Lexapro might be effective at lower doses. The post delves into studies on antidepressant dosing, the unique properties of Lexapro, and the potential benefits and risks of higher doses. Scott concludes that while there's no strong evidence for high doses of any antidepressant being more effective, prescribing higher doses of Lexapro might be as safe as other SSRIs and potentially more beneficial in some cases. Shorter summary

Scott Alexander analyzes the PANDA Study, a large real-world antidepressant trial, discussing its methodology, results, and implications for understanding antidepressant efficacy. Longer summary

This post discusses the PANDA (Prescribing ANtiDepressants Appropriately) Study, the largest non-pharma antidepressant trial ever conducted. The study aimed to measure the real-world efficacy of antidepressants, specifically sertraline, in a naturalistic setting. Scott Alexander analyzes the results, which show small to low-medium effect sizes for various depression and anxiety measures. He notes that while the effects are modest, they are not clinically insignificant. The study found that patient-reported improvement had a higher effect size than researcher-measured tests, potentially indicating a disconnect between clinical measures and patient experiences. Scott discusses the implications of these findings for antidepressant efficacy and suggests that targeted treatment approaches might yield better results. Shorter summary

Scott Alexander reviews evidence on face mask effectiveness against coronavirus, concluding they likely offer some protection despite CDC recommendations against general public use. Longer summary

This post examines the effectiveness of face masks in preventing coronavirus transmission. It reviews theoretical reasons, case-control studies, randomized trials, and laboratory studies on surgical masks and N95 respirators. The author concludes that while not perfect, surgical masks likely offer some protection against infection in high-risk situations. The post also discusses the CDC's recommendations against mask use for the general public, suggesting this may be due to high standards of proof in medical communication rather than intentional deception. The author ultimately recommends considering mask use in high-risk situations if supplies are not limited, while emphasizing that masks are not a substitute for avoiding such situations when possible. Shorter summary

Scott Alexander reviews his intellectual progress in the 2010s across various fields, crediting his blog for accelerating learning. Longer summary

Scott Alexander reflects on the intellectual progress he made in the 2010s, largely tracked through his blog posts. He discusses major updates in his understanding of topics like predictive coding theory, psychedelics, mental health, SSRIs, genetics, willpower, nutrition, x-risk, AI, scientific progress, cost disease, the replication crisis, placebo effect, ethics, politics, cultural evolution, social justice, game theory, and enlightenment. He notes that while some were major shifts in position, many represent 'deconfusion' - gaining a better map of the problem space. Scott credits his blog and reader interactions for accelerating his learning in the latter half of the decade. Shorter summary

This post examines the pros and cons of using gene editing technologies in humans, discussing scientific, medical, and ethical considerations. Longer summary

This post discusses the potential uses, risks, and ethical implications of gene editing technologies in humans. It covers the science behind CRISPR, its safety and efficiency, the relationship between genetics and disease, and potential applications in treating conditions like cancer and HIV. The authors explore complex questions around genetic enhancement and 'designer babies', highlighting both the promise and perils of this technology. They conclude that while gene editing holds great potential, especially for certain genetic diseases, its use must be carefully regulated and ethically considered. Shorter summary

A diverse collection of links covering technology, science, economics, politics, and culture, including critiques of studies, interesting scientific findings, and current events. Longer summary

This post is a collection of links to various interesting articles, studies, and news items. It covers a wide range of topics including technology, science, economics, politics, and culture. Some highlights include: a list of places branding themselves as the next Silicon Valley, a study on declining fertility in dogs, critiques of bad scientific studies, an article on antidepressant tapering, data on value drift in effective altruism, and discussions on the Mueller Report's impact on media credibility. The post also includes links to various interesting facts, studies, and developments in fields such as nutrition, drug use, e-cigarettes, and urban development. Shorter summary

Scott Alexander shares a diverse collection of links covering AI, economics, politics, science, and culture, offering brief comments and insights on each topic. Longer summary

This post is a collection of links to various news articles, studies, and interesting tidbits. It covers a wide range of topics including AI, economics, politics, science, and culture. Some notable items include: a new AI that draws pictures based on captions, a study on the effectiveness of ballpoint pens for emergency tracheotomies, the cancellation of a basic income experiment, weaknesses in Xi Jinping's rule, and a study showing Hitler's speeches didn't measurably increase Nazi support. The post also touches on topics like climate change, antimalarial bed nets, polygenic scores for disease risk, and a replication of a famous psychology study on smiling and happiness. The tone is informative and occasionally humorous, with Scott providing brief comments or insights on many of the links. Shorter summary

Scott Alexander critically examines a major meta-analysis on antidepressant efficacy, noting potential biases and comparing its surprising drug rankings to his own previous analysis. Longer summary

This post reviews a major meta-analysis by Cipriani et al on the efficacy of antidepressants. The study claims to definitively show antidepressants work, but Scott notes it doesn't actually refute previous critiques about their effectiveness. He examines potential biases and methodological issues in the study, particularly around industry funding of trials. Scott also discusses the study's ranking of different antidepressants, noting some matches with conventional wisdom but also some surprising results. He compares these rankings to his own previous analysis, finding major discrepancies, and concludes by urging some caution in interpreting the study's results despite its impressive scope. Shorter summary

A collection of interesting links covering science, technology, culture, and economics, including updates on DNA malware, AI gaming, prison censorship, and various scientific studies. Longer summary

This is a link roundup post covering various interesting news and studies. Topics include DNA-encoded malware, AI in gaming, prison book bans, studies on therapy effectiveness, global inequality trends, and various scientific and cultural curiosities. The post follows Scott's typical link roundup format, providing brief commentary and context for each item, often with a mix of serious analysis and humorous observations. He covers both academic research and popular culture, maintaining his characteristic balance of intellectual rigor and accessibility. Shorter summary

Scott examines the phenomenon of Hungarian scientific geniuses in the early 20th century, attributing it to a high concentration of high-IQ Ashkenazi Jews in Budapest rather than exceptional education. Longer summary

Scott explores the phenomenon of Hungarian scientific geniuses in the early 20th century, initially attributed to exceptional education. He debunks this theory, showing that many of these geniuses were prodigies before formal schooling. Scott then reveals that all these geniuses were Jewish, linking their success to the high IQ of Ashkenazi Jews as explained by Cochran, Hardy, and Harpending's theory. He notes that Hungary, particularly Budapest, had an unusually high concentration of Jews at that time. The post concludes by discussing the tragic end of this golden age due to the Holocaust, and speculates on whether we've lost something unique from that era of scientific progress. Shorter summary

Scott Alexander shares a collection of interesting links and studies on various topics, including scientific research, cultural observations, and current events, with brief commentary on each. Longer summary

This post is a collection of links to various articles and studies, with brief commentary on each. The links cover diverse topics from science, anthropology, politics, and society, including findings about placebo effects in psychiatry, Mormon cultural origins, and college rankings. The format is informal, with Scott providing personal observations and sometimes humorous asides about each link. The post includes both academic studies and news articles, often focusing on unexpected or counterintuitive findings. Shorter summary

The post explores the complex relationship between smoking and schizophrenia, critiquing conflicting studies and cautioning against hasty conclusions about nicotine's effects on schizophrenia risk. Longer summary

This post examines the relationship between smoking and schizophrenia. It starts by noting the high prevalence of smoking among schizophrenics and discusses various theories for this, including the self-medication hypothesis. The author then analyzes two conflicting studies on whether smoking causes or prevents schizophrenia. One study suggests smoking increases risk, while another, which controls for confounders, indicates smoking may decrease risk. The post criticizes how the first study, despite being newer, ignores the contradictory findings of the second study. The author expresses frustration with this scientific approach and cautions against pushing people at risk of schizophrenia away from nicotine without stronger evidence. The post ends by noting that smoking definitely decreases Parkinson's Disease risk and reiterating that tobacco smoking is still harmful overall. Shorter summary

Scott Alexander critiques mass-produced medical recommendations, showing how they can oversimplify or misrepresent scientific evidence using vitamin D and niacin as examples. Longer summary

Scott Alexander critiques mass-produced medical recommendations, focusing on vitamin D and niacin supplements. He argues that popular sources like information graphics and websites often oversimplify or misrepresent the scientific evidence. Using vitamin D as an example, he shows how counting only positive studies can lead to misleading conclusions, as many larger studies and meta-analyses have found no benefit for cancer prevention or general health. He then discusses niacin, once thought beneficial but later found to be potentially harmful. Scott emphasizes the importance of considering all available evidence and being cautious about simplified recommendations. Shorter summary

Scott Alexander presents a roundup of recent medical and psychological studies, covering topics from UV light exposure to belief in science during stress. Longer summary

This post is a roundup of recent medical and psychological studies from June. Scott Alexander covers a wide range of topics, including UV light exposure benefits, gut microbiota research, obesity factors, iodine deficiency effects on intelligence, Medicare cost variations, ketamine for depression, hypothermia caps for chemotherapy patients, cruise ships as alternatives to assisted living, peer review effectiveness, genetic risk for schizophrenia and IQ, obesity rates in lesbians, oxytocin and pair-bonding, and belief in science during stressful situations. The tone is informative with occasional humorous or sarcastic comments. Shorter summary