Scott argues that aesthetic discussions wrongly conflate sensory delight with novelty and context, and that modern art's obsession with being part of a historical conversation has led to the abandonment of beauty in favor of mechanical innovation. Longer summary

Scott argues that discussions of artistic taste conflate multiple distinct concepts (sensory delight, novelty, pattern recognition, context, etc.) and that this conflation prevents clear thinking. He uses a parable about restaurant criticism to argue that we should isolate the direct aesthetic experience from contextual factors like novelty and provenance, similar to how medical trials control for placebo effects. He criticizes modern art and literature for prioritizing novelty and historical conversation over genuine beauty or transformation, using examples like the Angelus Novus painting (which inspired beautiful commentary despite being visually unimpressive) and the constraints on contemporary novels. Scott acknowledges the value of artistic innovation but argues that when artists can't successfully marry beauty with novelty, they should stick to traditional forms rather than produce endless variations of transgressive art that adds nothing meaningful to the conversation. Shorter summary

Scott's monthly roundup of interesting links covering AI policy developments, technology news, cultural observations, and scientific research from December 2025. Longer summary

This is Scott Alexander's monthly collection of links and commentary covering diverse topics. Major themes include AI policy battles (chip sales to China, regulation debates, political campaigns), startup news (Substrate fraud allegations, Tornyol mosquito drones), and scientific updates (COVID origins, Hitler's DNA, lactose intolerance). The post also covers cultural topics like the first millennial saint, Dimes Square commentary, and political polling about ideal Democratic candidates. Scott provides his characteristic mix of straightforward reporting, skeptical analysis, and occasional humor throughout the 53 linked items. Shorter summary

Scott reviews a paper by leading researchers attempting to determine AI consciousness through computational theories, critiques their conflation of access and phenomenal consciousness, and predicts society will inconsistently ascribe consciousness to AIs based on their social roles rather than their underlying architecture. Longer summary

Scott reviews a new paper by Yoshua Bengio, David Chalmers, and others that attempts to determine whether AI systems are conscious by examining computational theories of consciousness like Recurrent Processing Theory and Global Workspace Theory. The paper finds that current AIs lack the necessary 'something something feedback' mechanisms for consciousness, but future architectures could have them. Scott criticizes the paper for conflating access consciousness (ability to introspect) with phenomenal consciousness (inner experience), and argues that even if AIs satisfy these computational criteria, it's unclear whether they would truly have subjective experience. He predicts a paradox where society will treat some AIs (like companions) as conscious while denying consciousness to functionally identical AIs in other roles (like factory robots), similar to how we treat dogs versus pigs today. Shorter summary

A review of the synaptic plasticity and memory hypothesis arguing that it is insufficient to explain memory, and proposing a broader cellular processes and memory hypothesis that includes molecular and intracellular mechanisms. Longer summary

The post reviews the synaptic plasticity and memory (SPM) hypothesis, which claims that learning and memory are stored in changes to synaptic weights between neurons. Through several compelling examples, from cannibalism rituals to heart transplant stories and single-cell learning, the author argues that while the SPM hypothesis has been productive, it is incomplete and partially wrong. The post presents evidence that memory can be stored through non-synaptic mechanisms, and proposes an alternative called the cellular processes and memory (CPM) hypothesis, which suggests memory storage involves multiple molecular and intracellular processes beyond just synaptic weights. Shorter summary

Scott analyzes the sudden emergence of commercial trait-based embryo selection services, discussing both the scientific validity and ethical implications of selecting embryos for health outcomes, intelligence, and physical traits. Longer summary

Scott examines the recent development of commercial embryo selection services, particularly focusing on companies like Genomic Prediction, Orchid Health, Nucleus, and Herasight. He explains how the technology works, comparing different companies' claims and methodologies, and discusses both scientific challenges and ethical concerns. The post explores the potential benefits, like reduced disease risk and increased IQ, while acknowledging issues around cost, racial disparities, and social implications. A significant portion focuses on Herasight's critique of competitor Nucleus's scientific claims. The post concludes by placing this technology in the broader context of human enhancement and future technological developments. Shorter summary

A detailed review of a 1995 paper introducing the PDAPP mouse model for Alzheimer's disease, examining how its limitations were overlooked and shaped decades of potentially misguided Alzheimer's research. Longer summary

The post reviews a landmark 1995 paper introducing the PDAPP mouse model for Alzheimer's disease, analyzing how its technical achievements and limitations shaped three decades of Alzheimer's research. The author examines the paper's methodology, results, and claims, showing how the model's flaws - including extreme protein overexpression and lack of key disease features - were overlooked in favor of a compelling but incomplete amyloid cascade hypothesis, leading to years of failed drug development and missed opportunities to explore alternative approaches. Shorter summary

Scott Alexander refutes Stephen Skolnick's theory that schizophrenia is caused by gut microbes rather than genetics, showing why the evidence better supports schizophrenia being a complex genetic neurodevelopmental disorder. Longer summary

Scott Alexander responds to Stephen Skolnick's theory that schizophrenia is caused by gut microbes rather than genetics. He systematically dismantles Skolnick's arguments by showing that twin concordance rates are exactly what we'd expect from a genetic condition, that microbiological inheritance patterns don't match schizophrenia inheritance patterns, and that the gut bacteria evidence cited was likely caused by antipsychotic medication rather than being causative. He concludes by explaining why schizophrenia is best understood as a complex neurodevelopmental disorder with multiple contributing factors rather than having a single cause. Shorter summary

Scott explores the 'missing heritability' problem in genetics, where twin studies show traits like IQ and educational attainment are highly heritable but newer genomic methods find much lower heritability, analyzing various potential explanations for this discrepancy. Longer summary

The post examines the 'missing heritability' problem in genetics, where twin studies consistently show behavioral traits like IQ and educational attainment are substantially heritable (around 40-60%), while newer genomic methods find much lower heritability (around 15-20%). Scott reviews the history of behavioral genetics research, explains various study methodologies and their potential biases, and analyzes different hypotheses for this discrepancy. He examines whether twin studies might be flawed, whether newer methods might be missing important genetic effects, and whether educational attainment might be an unusually problematic trait to study. While acknowledging remaining mysteries, he tentatively concludes that twin studies are probably largely correct and that newer methods may be missing rare variants and genetic interactions. Shorter summary

Scott argues that philosophical zombies (beings without consciousness) would still report having qualia and conscious experiences, challenging a key argument in the p-zombie debate. Longer summary

Scott Alexander challenges a core argument in the philosophical zombie debate by suggesting that p-zombies (beings without consciousness) would still report having qualia and conscious experiences, just like humans do. He walks through how p-zombies would process and describe visual information, showing that they would need to use language similar to how we describe conscious experience. The post explores the implications of this for various philosophical positions on consciousness, though it acknowledges remaining difficulties in explaining subjective experience. Shorter summary

Scott reviews Bryan Caplan's book arguing that modern parents can relax their intensive parenting, while wrestling with whether this advice still applies in the age of smartphones and social media. Longer summary

Scott reviews Bryan Caplan's book 'Selfish Reasons To Have More Kids', exploring its main arguments about how parents today spend much more time on childcare than previous generations despite evidence that parenting style doesn't greatly affect outcomes. The post explores historical childcare data, the cultural shift away from letting kids play unsupervised, and modern challenges like screen time. Scott, dealing with his own twins, finds the book's advice about relaxing parenting standards compelling but struggles with modern concerns about phones and technology that weren't relevant when the book was written in 2011. Shorter summary

Scott shares 55 interesting links covering topics from AI poetry to religious movements, including updates on various projects, unusual historical events, and current developments in technology, politics, and society. Longer summary

This is Scott's monthly links post for December 2024, collecting various interesting stories and developments. The links cover a wide range of topics, from Steven Seagal's bizarre life trajectory to developments in AI and technology, including updates on previous ACX topics and grants. Many links relate to ongoing discussions in the rationalist and EA communities, including debates about effective altruism and charitable giving. The post also includes various curiosities from history, culture, and current events, with Scott often providing his own analysis or perspective on the items shared. Shorter summary

A diverse collection of news items, studies, and interesting facts from November 2024, covering topics from scientific discoveries to cultural phenomena. Longer summary

This post is a compilation of various news items, studies, and interesting facts from November 2024. It covers a wide range of topics including scientific discoveries, political events, technological advancements, cultural phenomena, and historical anecdotes. The post is structured as a numbered list, with each item briefly summarizing a piece of news or information. Some notable items include a new schizophrenia drug approval, YouGov polling results on various historical figures, findings on genetic IQ changes over time, and updates on AI technology and its implications. Shorter summary

The post argues against California's Proposition 36, claiming it will increase imprisonment without effectively reducing crime or drug use, and suggests alternative solutions. Longer summary

This post argues against California's Proposition 36, which aims to increase mandatory sentences for certain drug and theft crimes. The author contends that while Prop 36 will certainly imprison more people, it won't effectively combat crime. The post analyzes the proposition's impact on drug-related offenses and theft, using data to show that increased sentencing doesn't correlate with reduced drug use or crime rates. It also points out the lack of treatment resources required by the proposition and the potential negative impact on existing crime prevention programs. The author suggests that instead of longer sentences, California should focus on targeted interventions, increased police resources, and expanding treatment options for drug addiction. Shorter summary

A compilation of 50 diverse news items and links from September 2024, covering topics from politics and economics to science and technology. Longer summary

This post is a compilation of 50 diverse links and news items from September 2024. It covers a wide range of topics including politics, science, technology, economics, and social issues. Some notable items include discussions on kidney donation compensation, personality genetics, fertility rates in Israel, drug decriminalization in Oregon, AI regulation in California, and various political and economic analyses. The post also includes commentary on recent studies, books, and social phenomena. Shorter summary

Scott Alexander examines the surprisingly broad effects of GLP-1 drugs like Ozempic, exploring their mechanisms and speculating on why they seem to impact so many different conditions. Longer summary

Scott Alexander explores the wide-ranging effects of GLP-1 receptor agonist medications like Ozempic, which are approved for diabetes and obesity but show promise for many other conditions. He delves into the mechanisms behind their effects on diabetes, weight loss, and addiction, speculating on why these drugs seem to have such broad impacts. The post discusses how GLP-1 drugs work in the brain to reduce hunger and dampen reward systems, potentially explaining their effects on addiction. Scott also touches on their anti-inflammatory properties and potential benefits for neurodegenerative diseases, while cautioning that some reported effects may not replicate. Shorter summary

A review of 'The Family That Couldn't Sleep' by D. T. Max, discussing its exploration of prion diseases and their impact, with updated perspectives on the book's conclusions. Longer summary

This review discusses 'The Family That Couldn't Sleep' by D. T. Max, a book about prion diseases published in 2006. The review covers the book's exploration of various prion diseases, including fatal familial insomnia, kuru, mad cow disease, and chronic wasting disease. It highlights the book's focus on the historical, scientific, and cultural aspects of these diseases, as well as the key figures involved in prion research. The reviewer also provides updated information and critiques some of the book's conclusions in light of more recent research. Shorter summary

Scott Alexander investigates why self-reported IQ scores in online surveys are implausibly high, identifying issues with conversion tools, reporting bias, and unreliable tests. Longer summary

Scott Alexander investigates why self-reported IQ scores in online surveys seem implausibly high. He analyzes data from two surveys (Less Wrong 2014 and Clearer Thinking 2023) and identifies three main issues: 1) A popular SAT to IQ conversion tool was inaccurate, inflating scores. 2) Only the smartest people tend to report their SAT scores, skewing the sample. 3) Self-reported IQ test scores are often inflated or based on unreliable tests. After accounting for these factors, he estimates the average IQ of the Clearer Thinking sample at 111 and the Less Wrong sample at 128, which he considers more plausible. Shorter summary

Scott Alexander argues that schizophrenia should be described as predominantly genetic, addressing counterarguments and emphasizing the importance of this perspective for prevention strategies. Longer summary

Scott Alexander argues that it's fair and accurate to describe schizophrenia as predominantly genetic. He responds to various arguments against this characterization, comparing the situation to how we discuss smoking causing lung cancer. Scott emphasizes that while environmental factors play a role, genetic factors account for the majority of variance in schizophrenia risk. He argues that acknowledging the genetic nature of schizophrenia is important for developing effective prevention strategies, such as polygenic screening, rather than focusing solely on hard-to-control environmental factors. Shorter summary

Scott Alexander uses simulations to explain why seemingly counterintuitive arguments against the genetic basis of schizophrenia are misleading. Longer summary

Scott Alexander discusses two seemingly counterintuitive arguments against the genetic basis of schizophrenia and explains why they're not as compelling as they might appear. He uses a simplified simulation to demonstrate how a highly heritable disorder can have low twin concordance rates and why eliminating affected individuals doesn't significantly reduce prevalence in the next generation. The post aims to clarify common misunderstandings about polygenic disorders and their inheritance patterns. Shorter summary

Scott Alexander recounts his journey to fatherhood, blending personal experiences with broader reflections on progress, rationality, and the future his newborn twins will face. Longer summary

Scott Alexander shares his experience becoming a father to twins, intertwining personal anecdotes with philosophical reflections on parenthood, human progress, and the future. He starts with a humorous account of his fertility clinic visit, then describes the challenges of pregnancy and choosing names. The post explores the concept of children as 'surprisal-minimization engines' adapting to the world, and reflects on the advancements in child mortality and healthcare. Scott concludes by expressing both concern and hope for his children's future in a rapidly changing world, viewing them as 'ambassadors to the singularity'. Shorter summary

A collection of 47 diverse links and news items covering topics from religious practices to AI developments, with brief commentary on many items. Longer summary

This post is a collection of 47 diverse links and news items covering various topics. It includes discussions on religious practices, video games, political trends, scientific studies, AI developments, economic analyses, historical anecdotes, and cultural phenomena. The author provides brief commentary on many of the items, often with a mix of humor and critical analysis. The links range from academic studies and economic reports to quirky historical facts and contemporary cultural observations. Shorter summary

Scott Alexander defends effective altruism by highlighting its major accomplishments and arguing that its occasional missteps are outweighed by its positive impact on the world. Longer summary

Scott Alexander defends effective altruism (EA) against recent criticisms, highlighting its accomplishments in global health, animal welfare, AI safety, and other areas. He argues that EA has saved around 200,000 lives, equivalent to ending gun violence, curing AIDS, and preventing a 9/11-scale attack in the US. Scott contends that EA's achievements are often overlooked because they focus on less publicized causes, and that the movement's occasional missteps are minor compared to its positive impact. He emphasizes that EA is a coalition of people who care about logically analyzing important causes, whether broadly popular or not, and encourages readers to investigate and support the most beneficial causes. Shorter summary

A diverse collection of links and brief comments on recent developments in science, technology, politics, and society, ranging from climate change to AI developments to social experiments. Longer summary

This post is a collection of links and brief comments on various topics. It covers a wide range of subjects including climate change, AI developments, social experiments, scientific studies, political issues, and technological innovations. The author presents these topics with a mix of factual reporting, personal commentary, and sometimes humorous observations. The post touches on subjects like geoengineering, crypto for sex workers, AI art, fertility rates, dating apps, charity effectiveness, and many others. The author often provides links to original sources and sometimes offers his own analysis or opinion on the matters discussed. Shorter summary

The review of 'The Mind of a Bee' examines the cognitive abilities of bees, raising questions about their intelligence and potential consciousness. Longer summary

This book review of 'The Mind of a Bee' by Lars Chittka explores the complex cognitive abilities of bees, discussing their behaviors, brain structure, and potential for consciousness. The review covers topics such as the waggle dance, honeycomb construction, brain waves, and various experiments demonstrating bees' problem-solving skills. While not definitively answering whether bees are 'smart' or conscious, the review highlights the complexity of bee cognition and the challenges in studying animal intelligence. Shorter summary

A review of Joe Henrich's 'The Weirdest People in the World', examining its argument that the Western Church's marriage regulations led to WEIRD psychology and modern economic growth. Longer summary

This book review examines Joe Henrich's 'The Weirdest People in the World', which argues that the Western Church's Marriage and Family Program (MFP) dismantled intensive kinship networks, leading to WEIRD (Western, Educated, Industrialized, Rich, and Democratic) psychology and modern economic growth. The reviewer discusses the book's scientific approach to European history, its extensive coverage of various topics, and raises questions about the intentionality of historical actors and the future implications of WEIRD psychology. Shorter summary